ArticleClinicoEconomics and outcomes research : CEOR2026
Cost-Effectiveness Analysis of the High-Dose Trivalent Influenza Vaccine in the Elderly Population in Italy.
Article in ClinicoEconomics and outcomes research : CEOR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Influenza is a significant public health concern, particularly among the elderly, contributing to high morbidity, hospitalizations, and mortality, in addition to increased economic burden sustained by the Italian National Health Service (SSN). Traditional vaccines, ie, standard-dose trivalent inactivated influenza vaccine (TIV-SD), showed lower immunogenicity and effectiveness in older adults than in younger adults, as a result of the immunosenescence process and increased comorbidities. Enhanced formulations, such as the high-dose trivalent influenza vaccine (TIV-HD), have been introduced to address this gap. This study evaluates the cost-effectiveness of TIV-HD compared to TIV-SD for individuals ≥65 years of age in Italy. Patients and Methods: A cost-effectiveness analysis was performed using a population-based decision-analytic model from the perspective of the SSN, over a one-year time horizon. The model simulated clinical pathways for influenza-related events, including general practitioner visits, emergency department consultations, hospitalizations for cardiorespiratory complications, and mortality. Epidemiological and cost data were sourced from national databases and peer-reviewed literature. Three pricing scenarios were explored. The outcomes included life-years (LYs), quality-adjusted life years (QALYs), and healthcare costs, allowing the calculation of the incremental cost-effectiveness ratio (ICER). Results: Model-based results showed that TIV-HD is a dominant strategy over TIV-SD, yielding both improved health outcomes (14,070 LYs and 13,678 QALYs) and cost savings in all the pricing scenarios explored. When applied to the Italian elderly population eligible for seasonal influenza vaccination, TIV-HD was estimated to generate overall savings ranging from €82.3 million and €135.0 million for the National Health Service, driven by the prevention of approximately 50,000 influenza-related hospitalizations. Conclusion: This analysis indicates that TIV-HD was associated with improved outcomes and lower overall costs compared with TIV-SD under the modeled assumptions. The enhanced clinical effectiveness combined with significant cost reductions underscores TIV-HD as a cost-effective intervention, contributing to sustainable healthcare management in Italy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.