ArticleFrontiers in cardiovascular medicine2026
Long-term single antiplatelet therapy for patients with acute coronary syndrome at high-risk for ischemia and bleeding: a precision cohort study.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: To compare the prognostic effects of different single antiplatelet therapy (SAPT) regimens (aspirin vs. clopidogrel) in patients with acute coronary syndrome (ACS) at high-risk for ischemia and bleeding following percutaneous coronary intervention (PCI) and switching from 12 months of dual antiplatelet therapy (DAPT) to SAPT. Methods: This study retrospectively analyzed 642 patients with ACS at high-risk of ischemia and bleeding who underwent PCI at a single-center between January 2017 and November 2022. After transitioning to SAPT, the cohort was divided into two groups based on the prescribed therapy: aspirin ( Results: The incidence of NACE was comparable between the two patient groups. However, the clopidogrel group had a lower incidence of MACCE (4.3% vs. 9.2%, Conclusion: In patients with ACS at high-risk, transitioning to clopidogrel as SAPT after 12 months of DAPT and successful PCI was associated with a reduced incidence of MACCE and TVR compared to aspirin, without an increased risk of major bleeding events.
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