ArticleIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine2026
Comparison of Clinical Profile and Outcomes Associated with Adenovirus and Non-adenovirus Viral Pneumonia in Children Admitted to a Pediatric Intensive Care Unit: A Single-center Retrospective Study.
Article in Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Severe adenovirus (AdV) pneumonia is a significant cause of morbidity and mortality in pediatric intensive care units (PICUs). This study aims to compare the clinical profile, laboratory parameters, radiological findings, and outcomes of children with severe AdV pneumonia with non-AdV viral pneumonia. Patients and methods: We conducted a retrospective review of case records of children diagnosed with viral pneumonia through PCR analysis of nasopharyngeal/throat swabs or bronchoalveolar lavage. Outcomes assessed included all-cause mortality, need for mechanical ventilation, duration of PICU and hospital stay, and incidence of bronchiolitis obliterans (BO) in each group. Univariate and multivariate logistic regression analyses were performed to identify risk factors for mortality and BO in the entire cohort. Results: Among 148 children with severe pneumonia, 63 (42.5%) had one or more viral isolates: AdV (31, 49.2%) and non-AdV viruses (32, 50.7%). The clinical profiles of the AdV and non-AdV viral pneumonia groups were comparable, except that all children in the AdV group were under 5 years of age [32 (100%) vs 26 (81.2%), ( Conclusion: While the overall clinical profile and short-term outcomes of severe AdV and non-AdV viral pneumonia are similar, children with AdV pneumonia are younger, more prone to leukopenia, and at a higher risk of developing BO. How to cite this article: Agarwal S, Patra B, Goyal N, Nanda S, Yadav S, Malik A,
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