ReviewRomanian journal of ophthalmology
Innovations in Corneal Transplantation: The Role of Eye Banks, Donor Corneas, and Artificial Alternatives in Combating Worldwide Corneal Blindness.
Review in Romanian journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: Corneal disorders-including degeneration, dystrophy, infection, and inflammation-rank as the fifth leading cause of global visual impairment. In developing regions, conditions such as trachoma and xerophthalmia further increase this burden. This review explores the current landscape, challenges, and advancements in corneal blindness management, with a focus on the role of eye banks and keratoplasty techniques. Objectives: (i) Assess global burden and causes of corneal blindness; (ii) Highlight eye banks' roles in donor tissue management; (iii) Identify challenges in eye banking and transplantation; (iv) Evaluate keratoplasty procedures; (v) Examine surgical innovations and therapies such as corneal collagen cross-linking. Methodology: A comprehensive literature review was conducted, analyzing peer-reviewed publications, health reports, and clinical guidelines. Data from both developed and developing countries were considered to provide a holistic perspective. Discussion: Corneal transplantation remains the most effective treatment for advanced corneal blindness; however, a significant gap persists between the demand for donor corneas and their availability. Advances in preservation techniques and the shift toward lamellar keratoplasty have improved graft survival and visual outcomes. Nevertheless, limited donor awareness and infrastructural constraints continue to affect successful implementation. Conclusion: Advanced keratoplasty methods-Penetrating Keratoplasty, Deep Anterior Lamellar Keratoplasty, and Endothelial Keratoplasty-have improved outcomes by reducing rejection and accelerating recovery. The adoption of femtosecond laser technology has enhanced surgical precision. Corneal collagen cross-linking now offers a minimally invasive option to delay or prevent transplant in ectatic conditions. Despite these advancements, global eye banks face persistent challenges in donor recruitment, tissue preservation, and ethical management. Continued innovation, improved infrastructure, and strengthened public health efforts are crucial to overcoming these barriers and reducing the global burden of corneal blindness.
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Registered trials
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