Hemorrhagic giant retinal cyst: a rare complication of a retinal vasoproliferative tumor.

Objective: To present a rare case of a giant cyst with intralesional hemorrhage associated with a peripheral retinal vasoproliferative tumor (RVPT). Methods: A 57-year-old male with vision loss in the right eye had an epiretinal membrane. Surgery revealed a yellowish-red mass with a large cyst in the retina, which was diagnosed as a peripheral RVPT. The lesion was observed until intralesional hemorrhage and progressive growth developed. Results: Intravitreal anti-VEGF injection reduced intralesional bleeding, and external cryotherapy achieved regression and stability of both the tumor and the cyst. Discussion: The differential diagnoses for this entity primarily included other retinal tumors and pars plana cysts. We suspected that this rare presentation of RVPT associated with a giant cyst might be due to contraction of the glial tissue. Intralesional hemorrhage resulting from vascular penetration inside the cyst was resolved with intravitreal anti-VEGF treatment, resulting in intrinsic vascular regression. Conclusion: Giant haemorrhagic retinal cysts are a rare, previously undescribed complication of peripheral retinal vasoproliferative tumours, in which anti-VEGF therapy may reduce bleeding.