ArticleFrontiers in pediatrics2026
Ultrasonographic optic nerve sheath diameter as a non-invasive marker of intracranial hypertension in pediatric patients: a pilot study.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Intracranial hypertension (IH) is a potentially life-threatening condition in pediatric patients that requires early recognition. Ultrasonographic measurement of optic nerve sheath diameter (ONSD) has emerged as a promising non-invasive surrogate for intracranial pressure (ICP), although pediatric data remain limited and diagnostic thresholds are not well established. Objective: To evaluate the correlation between ONSD and directly measured ICP, and to determine an optimal ONSD cutoff for detecting intracranial hypertension in pediatric patients with closed fontanelles. Methods: This prospective observational pilot study included pediatric patients admitted to a tertiary care center who required lumbar puncture with ICP measurement. ONSD was measured using transocular ultrasound immediately prior to lumbar puncture, at 3 mm posterior to the globe. Mean bilateral ONSD values were used when available. Correlation between ONSD and ICP was assessed using Spearman's rho. Receiver operating characteristic (ROC) curve analysis was performed to determine the optimal cutoff for detecting intracranial hypertension (defined as ICP >27 cmH₂O). Results: Thirteen patients were included, yielding 15 paired ONSD-ICP measurements. Median ONSD was 6.20 mm (IQR 5.68-6.53), and median ICP was 34 cmH₂O (IQR 26-44). A significant positive correlation was observed between ONSD and ICP (Spearman's rho = 0.65, Conclusion: ONSD ultrasonography appears to be a feasible and promising non-invasive method for detecting intracranial hypertension in pediatric patients with closed fontanelles. An ONSD threshold of 6.1 mm may help identify elevated ICP, although larger multicenter studies are required to validate these findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.