Evidence map›Paper›PMID 42146920›Full record

Trial reportFrontiers in pediatrics2026

The efficacy and safety of combined 0.01% atropine and orthokeratology for childhood myopia control: a 2-year randomized clinical trial.

Ying Yuan, Yuqi Deng, Chengcheng Zhu, Xinting Liu, Wei Zhang, Bingru Zheng, Xinjie Mao, Xiao Yang, Bilian Ke

Abstract readClinical Trial
In one paragraph

Trial report in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ying Yuan *Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuqi Deng *Department of Ophthalmology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chengcheng ZhuDepartment of Ophthalmology, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, China.
Xinting LiuNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Wei ZhangBiomedical Informatics & Statistics Center, School of Public Health, Fudan University, Shanghai, China.
Bingru ZhengShenzhen Eye Hospital, Jinan University, Shenzhen Eye Institute, Shenzhen, China.
Xinjie MaoNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Xiao YangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat-Sen University, Guangzhou, China.
Bilian KeDepartment of Ophthalmology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To explore the efficacy and safety of combined low-concentration atropine and orthokeratology lenses (AOK) for slowing the progression of myopia. Methods: In this randomized, placebo-controlled, double-blinded, multicenter clinical trial. Children ( Results: Over the 24 months, the axial elongation was significantly slower in the AOK group than in the OK group (0.33 ± 0.17 mm vs. 0.43 ± 0.16 mm, respectively; Conclusion: The combination of 0.01% atropine and orthokeratology produced a combined effect in slowing axial elongation over 2 years, with good tolerability and minimal ocular surface impact. Clinical Trial Registration: https://www.chictr.org.cn/showprojEN.html?proj=29216, identifier ChiCTR1800018419.

Indexed as

0.01% atropinechildhood myopiamulticenter trialmyopia controlorthokeratology

Identifiers

PMID42146920
PMCPMC13171514

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.