ArticleInternational journal of veterinary science and medicine2026
Novel LC-MS/MS Method for Monitoring Perfluoroalkyl and Polyfluoroalkyl Substances in Companion Animal Blood Plasma and Serum: Environmental and Health Implications.
Article in International journal of veterinary science and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- An investigation of per- and polyfluoroalkyl concentrations in dogs and cats with endocrine disorders.Frontiers in veterinary science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Per- and poly-fluoroalkyl substances (PFAS), known as "forever chemicals," are synthetic compounds widely used for their unique physicochemical properties. Their environmental persistence and potential link to adverse health outcomes have raised significant concerns, necessitating robust monitoring methods. While numerous studies have quantified PFAS in human biological fluids, there is a critical gap in the availability of validated analytical techniques for companion animals remain scares. Aims and Objectives: The aim of this study was to develop and validate a novel analytical method for the quantification of eleven PFAS in biological samples from companion animals, specifically canine serum and feline plasma, and to apply this method to real samples. Materials and Methods: A streamlined sample preparation protocol was developed including protein precipitation, evaporation under nitrogen at 45°C, and reconstitution. Quantification was performed by ultra-high-performance liquid chromatography-tandem mass spectrometry in negative electrospray mode, monitoring two transitions for each compound. Results: The method was validated according to European Medicines Agency guidelines and demonstrated excellent analytical performance, with strong linearity ( Conclusion: The validated UHPLC-MS/MS method provides a reliable and efficient tool for the biomonitoring of PFAS in companion animals. Its application enables large-scale assessment of environmental exposure and supports the evaluation of potential health implications for both pets and their owners.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.