ArticleEJHaem2026
Association Between Micronutrients and Cognitive Performance Among Adolescents and Young Adults Living With Sickle Cell Disease in Kumasi, Ghana: A Cross-Sectional Study.
Article in EJHaem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aim: Cognitive deficits are commonly reported in patients with sickle cell disease (SCD). Dietary micronutrient intake is a potential modifiable risk factor whose relationship with cognition in SCD patients remains poorly characterised. This study aimed to determine the association between dietary micronutrient intake and cognition among these cohorts. Methods: Among 128 participants were 64 stable SCD patients (Group-1) and 64 non-SCD community controls (Group-2), aged 13-24 years. A comparative cross-sectional study was conducted. Recruitment occurred in the same community catchment area served by the KNUST University Hospital SCD clinic. A 24-h dietary recall and the digit span test (DST) were used for dietary intake and cognition assessment, respectively. Mann-Whitney Results: Females constituted 73.4% of the SCD and 68.8% of the control group. The respective mean ages of Group-1 and Group-2 were 19.7 (±1.5) and 20.1 (±1.6) years ( Conclusion: There was no dietary micronutrient independently associated with cognitive performance after adjustment for multiple comparisons. However, niacin and selenium exhibited biologically plausible trends that warrant further investigation. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.
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