ArticleBrain communications2026
Functional neuroanatomy of musical object processing in Alzheimer's disease and frontotemporal dementia.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Music, besides its emotional and social resonance, models a complex sensory environment exemplifying auditory objects corresponding to sources (musical instruments) and information streams (melodies). These musical dimensions can be variably preserved or blighted by neurodegenerative disease. Music is, therefore, an attractive way to investigate the neural mechanisms of sensory object processing in these diseases. Here, we assessed the functional neuroanatomy underlying the perceptual, semantic, and apperceptive processing of musical objects in Alzheimer's disease and temporal variant frontotemporal dementia. We studied 35 patients (20 Alzheimer's disease, 15 temporal variant frontotemporal dementia; 14 females; mean [standard deviation] age 70.3 [8.4] years) in relation to 25 cognitively healthy volunteers (16 females; age 69.5 [6.8] years). In a functional MRI experiment with sparse image acquisition to minimise the impact of scanner noise, participants passively listened to monophonic melodies. We varied timbre (same/change), timbre familiarity (natural/artificial instruments), melody familiarity (familiar/novel), and apperception (melodies with interpolated timbre changes); these manipulations allowed us to assess the functional neuroanatomical correlates of musical feature perception, melody familiarity, constancy, novelty, and instrument familiarity. Behavioural correlates were assessed in post-scan tasks and disease-related atrophy patterns using voxel-based morphometry of participants' structural scans. All contrasts were assessed at
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