Evidence map›Paper›PMID 42146810›Full record

ArticleAnnals of gastroenterological surgery2026

Prognostic and Predictive Role of Lymph Node Count in Stage II Colon Cancer: A Retrospective Analysis of a Japanese Nationwide Cohort.

Kozo Kataoka, Akira Ouchi, Kanae Takahashi, Kazuma Ito, Manabu Shiozawa, Kenta Iguchi, Takashi Akiyoshi, Takefumi Yoshida, Masataka Ikeda, Eiji Shinto and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of gastroenterological surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kozo KataokaDivision of Lower GI Surgery, Department of Gastroenterological Surgery Hyogo Medical University Nishinomiya Japan.ORCID https://orcid.org/0000-0003-2043-8184
Akira OuchiDepartment of Gastroenterological Surgery Aichi Cancer Center Hospital Nagoya Japan.ORCID https://orcid.org/0000-0003-0435-5370
Kanae TakahashiDepartment of Medical Statistics Osaka Metropolitan University Osaka Japan.
Kazuma ItoDivision of Lower GI Surgery, Department of Gastroenterological Surgery Hyogo Medical University Nishinomiya Japan.
Manabu ShiozawaDepartment of Gastrointestinal Surgery Kanagawa Cancer Center Yokohama Japan.
Kenta IguchiDepartment of Gastrointestinal Surgery Kanagawa Cancer Center Yokohama Japan.
Takashi AkiyoshiDepartment of Colorectal Surgery, Gastroenterological Center Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan.ORCID https://orcid.org/0000-0002-2321-1412
Takefumi YoshidaDepartment of Surgery Kurume University School of Medicine Kurume Japan.
Masataka IkedaDivision of Lower GI Surgery, Department of Gastroenterological Surgery Hyogo Medical University Nishinomiya Japan.ORCID https://orcid.org/0000-0001-9602-6659
Eiji ShintoDepartment of Surgery Self-Defense Forces Central Hospital Tokyo Japan.
Yasuyuki TakamizawaDepartment of Colorectal Surgery National Cancer Center Hospital Chuo City Japan.ORCID https://orcid.org/0000-0002-9751-3309
Yoichi AjiokaDivision of Molecular and Diagnostic Pathology Niigata University, Graduate School of Medical and Dental Sciences Niigata Japan.
Hirotoshi KobayashiDepartment of Surgery Teikyo University Mizonokuchi Hospital Kawasaki Japan.ORCID https://orcid.org/0000-0002-4381-0439
Yukihide KanemitsuDepartment of Colorectal Surgery National Cancer Center Hospital Chuo City Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: This study aimed to reevaluate the prognostic significance of the number of harvested lymph nodes (LNs) and its predictive value for adjuvant chemotherapy (ACT) in stage II colon cancer (CC), considering tumor sidedness. Methods: Pathological stage II CC patients who underwent curative surgery with Japanese D3 lymphadenectomy were assessed using a Japanese database. The optimal cutoff for harvested LNs was evaluated by analyzing all cutoff values ( Results: A total of 3526 (left/right; 2684/842) pathological stage II CC patients were identified. A cutoff of 12LNs was identified as a prognostic factor for OS (HR 1.45; [95% CI: 1.15-1.82]). However, a stronger prognostic impact was observed with a cutoff of seven (HR 2.04; [1.44-2.88]). Subgroup analysis based on sidedness revealed variations in the optimal cutoff (7 for left-sided [HR 2.25; (1.54-3.280)]) and 10 for right-sided (HR 1.82; [1.02-3.26]). The survival benefit of ACT was not observed across all cutoffs. Conclusion: Although cutoffs other than 12 LNs demonstrated stronger prognostic value in certain subgroups, harvesting ≥ 12 LNs remained a consistent prognostic factor across sidedness. The number of harvested LNs may not be a useful predictive factor of ACT in stage II CC.

Indexed as

12 harvested lymph nodescolon cancerstage II

Identifiers

PMID42146810
PMCPMC13178267

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.