Evidence map›Paper›PMID 42146762›Full record

ArticleResearch (Washington, D.C.)2026

"Dual-Boosting" Strategy to Enhance Radical Generation of Photosensitizer for Mitochondria-Targeted Phototherapy.

Limin Wang, Dongming Wu, Haolin Zhang, Panpan Li, Hui Liu, Biying Zhang, Jiacong Yan, Yunxiu Li, Bo Peng, Wenbo Hu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Limin WangState Key Laboratory of Flexible Electronics (LoFE) & Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi'an 710072, China.
Dongming WuState Key Laboratory of Flexible Electronics (LoFE) & Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi'an 710072, China.
Haolin ZhangState Key Laboratory of Flexible Electronics (LoFE) & Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi'an 710072, China.
Panpan LiState Key Laboratory of Flexible Electronics (LoFE) & Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi'an 710072, China.
Hui LiuState Key Laboratory of Flexible Electronics (LoFE) & Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi'an 710072, China.
Biying ZhangState Key Laboratory of Flexible Electronics (LoFE) & Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi'an 710072, China.
Jiacong YanCenter of Reproductive Medicine, NHC Key Laboratory of Healthy Birth and Birth Defect Prevention in Western China, First People's Hospital of Yunnan Province, Kunming 650500, China.
Yunxiu LiCenter of Reproductive Medicine, NHC Key Laboratory of Healthy Birth and Birth Defect Prevention in Western China, First People's Hospital of Yunnan Province, Kunming 650500, China.
Bo PengState Key Laboratory of Flexible Electronics (LoFE) & Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi'an 710072, China.
Wenbo HuState Key Laboratory of Flexible Electronics (LoFE) & Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi'an 710072, China.
Bin FangState Key Laboratory of Flexible Electronics (LoFE) & Institute of Flexible Electronics (IFE), Xiamen University, Xiamen 361102, China.
Hua BaiState Key Laboratory of Flexible Electronics (LoFE) & Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi'an 710072, China.
Lin LiState Key Laboratory of Flexible Electronics (LoFE) & Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi'an 710072, China.ORCID https://orcid.org/0000-0003-0426-6546

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organelle-targeted photodynamic therapy (PDT) shows substantial promise for precision tumor treatment. However, the clinical translation of oxygen-independent photosensitizers (PSs) designed for mitochondrial localization remains challenging. Herein, we propose a "dual-boosting" strategy to enhance the type-I PDT efficacy of mitochondria-targeted PSs. The first boost leverages multi-branched donor/π-bridge engineering to develop a series of mitochondria-targeted pyrido cyanines. Among them, McL3 displays broad visible-light absorption and a reduced singlet-triplet energy gap (Δ

Identifiers

PMID42146762
PMCPMC13172578

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.