Evidence map›Paper›PMID 42146705›Full record

ArticlebioRxiv : the preprint server for biology2026

Decoding the

Anna Gabrielle Horacek, Frances Li Kueper, Robert Lu, Isabella Paige Lamont, Stella Tran, Hanqin Li, Dirk Hockemeyer

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anna Gabrielle HoracekDepartment of Molecular and Cell Biology, University of California, Berkeley; Berkeley, CA 94720, USA.ORCID 0000-0002-5984-9434
Frances Li KueperDepartment of Molecular and Cell Biology, University of California, Berkeley; Berkeley, CA 94720, USA.
Robert LuDepartment of Molecular and Cell Biology, University of California, Berkeley; Berkeley, CA 94720, USA.ORCID 0000-0001-7483-9691
Isabella Paige LamontDepartment of Molecular and Cell Biology, University of California, Berkeley; Berkeley, CA 94720, USA.ORCID 0009-0000-2451-5744
Stella TranDepartment of Molecular and Cell Biology, University of California, Berkeley; Berkeley, CA 94720, USA.
Hanqin LiInnovative Genomic Institute, University of California, Berkeley; Berkeley, CA 94720, USA.
Dirk HockemeyerDepartment of Molecular and Cell Biology, University of California, Berkeley; Berkeley, CA 94720, USA.ORCID 0000-0002-5598-5092

Funding

Molecular Genetics of the Telomere Biology DisordersR01HL131744 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BERTUCH, ALISON A, HOCKEMEYER, DIRK · 2016 to 2025
$4.5M
Elucidating the structure function relationship between TPP1 and telomere length control through deep scanning mutagenesisR21AG095841 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI HOCKEMEYER, DIRK · 2025 to 2025
$413k
NHLBI NIH HHS R01 HL131744NIA NIH HHS R21 AG095841
6 · The paper itself

Abstract

Reversion mutations that restore BRCA2 function represent a major mechanism of resistance to poly(ADP-ribose) polymerase inhibitors (PARPi) in

Indexed as

BRCAbreastgenetic reversionovarianPARP inhibitor resistanceprostate cancer

Identifiers

PMID42146705
PMCPMC13174588

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.