Evidence map›Paper›PMID 42146699›Full record

ArticlebioRxiv : the preprint server for biology2026

Precision Aptamers Against a Native GPCR through Ligand-Guided Selection.

Agbor Otu Egbe Vydaline, Mitali Bhate, Divyani Sitaldin, Yilam Ng Cen, Sergei Rozhkov, German Sosa, Amedee des Georges, Prabodhika Mallikaratchy

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Agbor Otu Egbe VydalinePh.D. Program in Biochemistry, CUNY Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016.
Mitali BhatePh.D. Program in Biochemistry, CUNY Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016.
Divyani SitaldinDepartment of Chemistry and Biochemistry, City College, City University of New York, New York, NY 10031.
Yilam Ng CenPh.D. Program in Biology, CUNY Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016.
Sergei RozhkovPh.D. Program in Biology, CUNY Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016.
German SosaDepartment of Chemistry and Biochemistry, City College, City University of New York, New York, NY 10031.
Amedee des GeorgesPh.D. Program in Biochemistry, CUNY Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016.
Prabodhika MallikaratchyPh.D. Program in Biochemistry, CUNY Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016.ORCID 0000-0002-6437-4613

Funding

G-RISE: Graduate Research Initiative for Student Advancement at The City College of New YorkT32GM136499 · NIGMS · CITY COLLEGE OF NEW YORK · PI RUTH E. STARK · 2020 to 2026
$4.9M
Discovery and development of artificial nucleic acid ligands to probe cellular interactionsR35GM139336 · NIGMS · HERBERT H. LEHMAN COLLEGE · PI MALLIKARATCHY, PRABODHIKA · 2021 to 2025
$1.9M
U-RISE at City College of New YorkT34GM149459 · NIGMS · CITY COLLEGE OF NEW YORK · PI JONATHAN B LEVITT · 2023 to 2026
$882k
NIGMS NIH HHS R35 GM139336NIGMS NIH HHS T32 GM136499NIGMS NIH HHS T34 GM149459
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) constitute the largest and most diverse class of membrane receptors encoded in the human genome. They detect a wide range of chemical and physical stimuli and transduce these signals into intracellular responses through highly regulated pathways. Reflecting their central role in physiology, GPCRs are among the most prominent targets in drug discovery. However, identifying ligands that recognize GPCRs in their native conformational and membrane context remains a significant challenge. Here, we report an expanded aptamer discovery platform based on ligand-guided selection (LIGS) to isolate aptamers against GPCRs in their native cellular state. Using the β

Indexed as

DNA aptamerdrug discoveryG protein-coupled receptorligand-guided selection (LIGS)molecular probesβ2 adrenergic receptor

Identifiers

PMID42146699
PMCPMC13174393

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.