Evidence map›Paper›PMID 42146687›Full record

ArticlebioRxiv : the preprint server for biology2026

Gene-Modulated Network Diffusion for Improved Modeling of Amyloid-

Frederick H Xu, Duy Duong-Tran, Heng Huang, Andrew J Saykin, Paul M Thompson, Christos Davatzikos, Yize Zhao, Li Shen

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Frederick H XuUniversity of Pennsylvania.ORCID 0000-0001-9877-0481
Duy Duong-TranUniversity of Pennsylvania.ORCID 0009-0009-4496-7575
Heng HuangUniversity of Maryland.ORCID 0000-0002-3483-8333
Andrew J SaykinIndiana University.ORCID 0000-0002-1376-8532
Paul M ThompsonUniversity of Southern California.ORCID 0000-0002-4720-8867
Christos DavatzikosUniversity of Pennsylvania.ORCID 0000-0002-1025-8561
Yize ZhaoYale University.ORCID 0000-0001-6283-2302
Li ShenUniversity of Pennsylvania.ORCID 0000-0002-5443-0503

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITEU24AG041689 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LI-SAN WANG · 2012 to 2026
$42.3M
Peripheral and Central Biomarkers of Alzheimer's Disease in Diverse CohortsU19AG074879 · NIA · MAYO CLINIC JACKSONVILLE · PI Minerva Maria Carrasquillo · 2023 to 2026
$42.0M
Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
Artificial Intelligence Strategies for Alzheimer's Disease ResearchU01AG066833 · NIA · CEDARS-SINAI MEDICAL CENTER · PI MOORE, JASON H., RITCHIE, MARYLYN D · 2022 to 2025
$6.7M
Translational big data analytic approaches to advance drug repurposing for Alzheimer's diseaseR01AG071470 · NIA · UNIVERSITY OF PENNSYLVANIA · PI KIM, DOKYOON, NING, XIA · 2021 to 2025
$3.8M
Novel integrative imaging genetics analysis for Alzheimer's disease riskand progressionRF1AG068191 · NIA · YALE UNIVERSITY · PI ZHAO, YIZE · 2021 to 2021
$1.9M
Cross-disciplinary training in translational neuroimaging of ADRDT32AG076411 · NIA · UNIVERSITY OF PENNSYLVANIA · PI JOHN A DETRE, MURRAY GROSSMAN · 2022 to 2026
$1.5M
Topological Machine Learning to Characterize Higher-Order Brain Connectivity Alterations in Alzheimer's DiseaseF31AG091902 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Frederick Hong Xu · 2025 to 2026
$100k
NIA NIH HHS F31 AG091902NIA NIH HHS R01 AG071470NIA NIH HHS RF1 AG068191NIA NIH HHS T32 AG076411NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG066833NIA NIH HHS U01 AG068057NIA NIH HHS U19 AG074879NIA NIH HHS U24 AG041689
6 · The paper itself

Abstract

Understanding the pathogenesis of amyloid-

Indexed as

Alzheimer’s diseaseneuroimagingneuropathologypositron emission tomographytranscriptomics

Identifiers

PMID42146687
PMCPMC13174398

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.