Evidence map›Paper›PMID 42146665›Full record

ArticlebioRxiv : the preprint server for biology2026

Thermodynamics of Indirect Readout in Cre-

Jonathan S Montgomery, Megan E Judson, Robert M Bauer, Matthew J Benedek, Caroline E Hervey, Mark P Foster

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jonathan S MontgomeryThe Ohio State Biochemistry Program, The Ohio State University, Columbus, 43210, United States of America.ORCID 0000-0003-2463-6671
Megan E JudsonDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, 43210, United States of America.ORCID 0009-0003-8776-3771
Robert M BauerDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, 43210, United States of America.
Matthew J BenedekThe Ohio State Biochemistry Program, The Ohio State University, Columbus, 43210, United States of America.ORCID 0000-0002-2037-8559
Caroline E HerveyDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, 43210, United States of America.
Mark P FosterThe Ohio State Biochemistry Program, The Ohio State University, Columbus, 43210, United States of America.ORCID 0000-0001-9645-7491

Funding

TRD3 NMRbox: Bayesian AnalyticsP41GM111135 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HOCH, JEFFREY C · 2015 to 2024
$14.0M
Cellular, molecular, and biochemical sciences training grantT32GM141955 · NIGMS · OHIO STATE UNIVERSITY · PI Jane Elizabeth Jackman, JESSE J KWIEK · 2021 to 2026
$2.2M
Molecular biophysics predoctoral training at the Ohio State UniversityT32GM144293 · NIGMS · OHIO STATE UNIVERSITY · PI CHARLES E BELL, Ralf A Bundschuh · 2022 to 2026
$1.1M
Protein Dynamics in Site-Specific DNA RecombinationR01GM122432 · NIGMS · OHIO STATE UNIVERSITY · PI FOSTER, MARK P. · 2017 to 2020
$1.1M
NIGMS NIH HHS P41 GM111135NIGMS NIH HHS R01 GM122432NIGMS NIH HHS T32 GM141955NIGMS NIH HHS T32 GM144293
6 · The paper itself

Abstract

Cre, a site-specific tyrosine DNA recombinase, enables targeted manipulation of genetic material without production of cytotoxic double-strand DNA breaks. Though widely deployed in biotechnology, an incomplete understanding of how Cre recognizes its cognate

Indexed as

Calorimetryinduced-fit recognitionmass photometryNMRsite-specific DNA recombination

Identifiers

PMID42146665
PMCPMC13174288

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.