Evidence map›Paper›PMID 42146656›Full record

ArticlebioRxiv : the preprint server for biology2026

Localized heme sensing through a ternary molecular glue.

Michael Heider, Clara Hipp, Zhi Yang, Han Xiao, Tobias Beschauner, Eddie Wehri, Wencke Walter, Rumi Sherriff, Srividya Chandrasekhar, Torsten Haferlach and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michael HeiderDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Clara HippDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Zhi YangDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Han XiaoDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Tobias BeschaunerDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Eddie WehriDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Wencke WalterMLL Munich Leukemia Laboratory, Munich, Germany.
Rumi SherriffDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Srividya ChandrasekharDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Torsten HaferlachMLL Munich Leukemia Laboratory, Munich, Germany.
Julia SchaletzkyDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Michael RapéDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.

Funding

Function and regulation of the reductive stress responseR01GM151335 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Michael P Rape · 2023 to 2026
$1.2M
NIGMS NIH HHS R01 GM151335
6 · The paper itself

Abstract

Molecular glues are an emerging class of therapeutics that stabilize binary interactions and there-by rewire disease-relevant protein networks. Whether glues can integrate additional information to orchestrate signaling beyond initial complex formation is unknown. Here, we report that cells use an endogenous glue strategy to sense heme, an essential metabolite with deleterious prooxidant properties. Distinct from other glues, heme bridges three polypeptides to trigger degradation of the transcriptional repressor BACH1 through cytoplasmic, but not mitochondrial, CUL2

Indexed as

AMLFEM1Bhememitochondriamolecular glueubiquitin

Identifiers

PMID42146656
PMCPMC13174492

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.