Evidence map›Paper›PMID 42146632›Full record

ArticlebioRxiv : the preprint server for biology2026

An Operant-based Touchscreen Morph Discrimination Task Does Not Detect Age-related Mnemonic Similarity Deficits in Rats.

Aleyna Ross, Carly N Logan, John J Thompson, Sarah A Johnson, Cory Watson, Maria Ramirez, Katelyn N Lubke, Andrew P Maurer, Sara N Burke

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Aleyna RossEvelyn F. McKnight Brain Institute, Center for Cognitive Aging and Memory, Department of Neuroscience, University of Florida, Gainesville, FL 32611, United States.
Carly N LoganEvelyn F. McKnight Brain Institute, Center for Cognitive Aging and Memory, Department of Neuroscience, University of Florida, Gainesville, FL 32611, United States.
John J ThompsonEvelyn F. McKnight Brain Institute, Center for Cognitive Aging and Memory, Department of Neuroscience, University of Florida, Gainesville, FL 32611, United States.
Sarah A JohnsonDeceased, contributed substantially to the conception and experimental design.
Cory WatsonEvelyn F. McKnight Brain Institute, Center for Cognitive Aging and Memory, Department of Neuroscience, University of Florida, Gainesville, FL 32611, United States.
Maria RamirezEvelyn F. McKnight Brain Institute, Center for Cognitive Aging and Memory, Department of Neuroscience, University of Florida, Gainesville, FL 32611, United States.
Katelyn N LubkeEvelyn F. McKnight Brain Institute, Center for Cognitive Aging and Memory, Department of Neuroscience, University of Florida, Gainesville, FL 32611, United States.
Andrew P MaurerEvelyn F. McKnight Brain Institute, Center for Cognitive Aging and Memory, Department of Neuroscience, University of Florida, Gainesville, FL 32611, United States.
Sara N BurkeEvelyn F. McKnight Brain Institute, Center for Cognitive Aging and Memory, Department of Neuroscience, University of Florida, Gainesville, FL 32611, United States.

Funding

The contribution of declines in functional connectivity to cognitive agingR01AG049722 · NIA · UNIVERSITY OF FLORIDA · PI BURKE, SARA N · 2016 to 2025
$3.2M
NIA NIH HHS R01 AG049722
6 · The paper itself

Abstract

The Mnemonic Similarity Task (MST) is highly sensitive to age-related cognitive decline in humans and has been adapted for rodents using 3D objects, where aged animals show deficits in discriminating similar lures. To improve translational alignment with human testing and increase automation, we developed a touchscreen-based rat analog using a morphed Object-Cued Spatial Choice (OCSC) task with 2D image stimuli. Young (4-month) and aged (21-month) male and female Fischer 344 × Brown Norway hybrid rats were trained in Bussey-Saksida touchscreen chambers and tested on discrimination performance using image pairs that varied parametrically in feature overlap. We also assessed perirhinal cortical engagement in a subset of animals using

Indexed as

hippocampusimmediate early genemnemonic similarity taskperirhinal cortexrat

Identifiers

PMID42146632
PMCPMC13174355

What OpenQuestion holds

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LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.