Evidence map›Paper›PMID 42146630›Full record

ArticlebioRxiv : the preprint server for biology2026

Cohesin extrudes chromatin loop unidirectionally through two modes of mechanisms in human cells.

Ping Wang, Lingyun Meng, Linghan Jiang, Yang Li, Jiaxiang Huang, Tiancheng Yu, Haoxi Chai, Minji Kim, Xiaotao Wang, Yijun Ruan

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ping WangRobert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine and Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Evanston, IL, 60201, USA.
Lingyun MengLife Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, 310058, P.R. China.
Linghan JiangInstitute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200032, China.
Yang LiLife Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, 310058, P.R. China.
Jiaxiang HuangLife Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, 310058, P.R. China.
Tiancheng YuLife Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, 310058, P.R. China.
Haoxi ChaiLife Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, 310058, P.R. China.
Minji KimGilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.
Xiaotao WangInstitute of Reproduction and Development, Shanghai Key Laboratory of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200032, China.
Yijun RuanLife Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Province, 310058, P.R. China.

Funding

Roles of allele-specific chromatin interactions in transcription regulation during developmentR00HG011542 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KIM, MINJI · 2023 to 2025
$731k
NHGRI NIH HHS R00 HG011542
6 · The paper itself

Abstract

Cohesin is crucial for establishing 3D genome organization and functions. However, the

Indexed as

3D genome organizationChromatin interactioncohesinCTCFloop extrusionsingle-molecule chromatin mapping

Identifiers

PMID42146630
PMCPMC13174533

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.