Evidence map›Paper›PMID 42146618›Full record

ArticlebioRxiv : the preprint server for biology2026

Nrf2 regulates ICAM-1-mediated neutrophil extracellular trap formation after traumatic brain injury.

P M Abdul Muneer, Saurav Bhowmick, Yemin A Poovanthodi, Saleena Alikunju

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

P M Abdul MuneerLaboratory of CNS Injury and Molecular Therapy, Department of Biomedical Engineering, Florida International University, 10555 West Flagler Street, Miami, FL-33174.ORCID 0000-0001-8231-4385
Saurav BhowmickJFK Neuroscience Institute, Hackensack Meridian Health JFK University Medical Center, 65 James St, Edison, NJ-08820, United States.
Yemin A PoovanthodiJFK Neuroscience Institute, Hackensack Meridian Health JFK University Medical Center, 65 James St, Edison, NJ-08820, United States.
Saleena AlikunjuMiami Project to Cure Paralysis, Lois Pope LIFE Center, Miller School of Medicine, University of Miami, 1095 NW 14th Terrace, Miami, FL 33136, United States.

Funding

Neutrophil extracellular traps and associated pathogenesis in TBI: a novel peptide therapeutic strategy.R01NS133233 · NINDS · HACKENSACK UNIVERSITY MEDICAL CENTER · PI Mohammed Abdul Muneer · 2024 to 2026
$1.3M
Peptide therapy for alcohol-induced CNS injuryR21AA030625 · NIAAA · HACKENSACK UNIVERSITY MEDICAL CENTER · PI MUNEER, MOHAMMED ABDUL · 2023 to 2024
$465k
NIAAA NIH HHS R21 AA030625NINDS NIH HHS R01 NS133233
6 · The paper itself

Abstract

Traumatic brain injury (TBI) triggers secondary neurovascular damage characterized by oxidative stress, blood-brain barrier (BBB) disruption, and neuroinflammation, leading to long-term cognitive deficits. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of cellular antioxidant defense, but its role in maintaining neurovascular integrity after TBI remains unclear. Here, using

Indexed as

antioxidantsICAM-1neutrophil extracellular trapsNrf2TBItransmigration

Identifiers

PMID42146618
PMCPMC13174394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.