Evidence map›Paper›PMID 42146603›Full record

ArticlebioRxiv : the preprint server for biology2026

Inhibition of p65 NF-κB enhances production of galactose-deficient IgA1 through suppression of

Taylor Person, Maggie Phillips, Terri Rice, Stacy Hall, Bruce A Julian, Dana V Rizk, Jan Novak, Colin Reily

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Taylor PersonDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Maggie PhillipsDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Terri RiceDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Stacy HallDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Bruce A JulianDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Dana V RizkDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jan NovakDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Colin ReilyDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-4033-1360

Funding

Elucidating IgA Nephropathy through Genetic Studies of IgA1 GlycosylationR01DK082753 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GHARAVI, ALI G, NOVAK, JAN · 2009 to 2024
$8.7M
Molecular Basis of Pathogenicity of IgA1-containing Immune ComplexesR01DK078244 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JAN NOVAK · 2007 to 2026
$6.0M
Distinct Glycophenotypes with Abnormal Signaling Define a Subpopulation of B cells Responsible for Production of Galactose-Deficient IgA1, the Main Autoantigen in IgA NephropathyR01DK134489 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Colin Robert Reily · 2023 to 2026
$1.9M
Molecular Basis of Pathogenicity of IgA1-containing Immune ComplexesR56DK078244 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NOVAK, JAN · 2012 to 2012
$92k
NIDDK NIH HHS R01 DK078244NIDDK NIH HHS R01 DK082753NIDDK NIH HHS R01 DK134489NIDDK NIH HHS R56 DK078244
6 · The paper itself

Abstract

IgA nephropathy (IgAN) is a common primary glomerulonephritis characterized by glomerular immune-complex deposits with (co)dominant IgA. These deposits are enriched for IgA1 glycoforms with some

Indexed as

Gd-IgA1 autoantigenIgA nephropathyNF-κBO-glycosylationSP1

Identifiers

PMID42146603
PMCPMC13174683

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.