Evidence map›Paper›PMID 42146592›Full record

ArticlebioRxiv : the preprint server for biology2026

Environmental Regulation and Gene-by-Environment Interaction Influence

Siddhant Kalra, Guadalupe Sanchez, Alexandra Stubin, Anya Le, Arpie Bakshian, Bianca Ortiz Diaz, Brianna Meiko Mark, Crystal Peña, Eliza Parker, Emma Johnston and 14 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Siddhant KalraDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.ORCID 0000-0003-2800-4559
Guadalupe SanchezDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.
Alexandra StubinDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.
Anya LeDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.
Arpie BakshianDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.ORCID 0009-0008-0794-6591
Bianca Ortiz DiazDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.
Brianna Meiko MarkDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.
Crystal PeñaDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.
Eliza ParkerDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.
Emma JohnstonDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.
Evan Edward HsuDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.
Gavin BranghamDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.
Idenya Bala-MehtaDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.
Luis Daniel PerezDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.ORCID 0009-0009-1881-5439
Maya Lee MilrodDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.
Meili StantenDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.ORCID 0009-0003-6554-0286
Mikoto NakamuraDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.
Pete HwangDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.
Sara Maria PtaszynskaDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.
Sasha CanderDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.
Sebin ParkDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.
Tai Lon TanDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.
Yancheng ZhouDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.
Joseph David CoolonDepartment of Biology, Wesleyan University, Middletown, CT 06457, United States of America.ORCID 0000-0003-1591-9418

Funding

Information flow through regulatory networksR15GM135901 · NIGMS · WESLEYAN UNIVERSITY · PI COOLON, JOSEPH DAVID · 2019 to 2019
$493k
NIGMS NIH HHS R15 GM135901
6 · The paper itself

Abstract

Gene-by-environment (GxE) interactions play a major role in shaping both phenotypic and molecular variation, with important implications for human health and disease. In this study, we used the Doxycycline (Dox) regulated, tetracycline-responsive (Tet-Off) promoter system to sequentially reduce or titrate gene expression levels of the essential yeast transcription factor

Indexed as

Environmental stressGene co-expression networksGene–environment interactionsNetwork analysisRAP1RNA sequencingSaccharomyces cerevisiaeTet-Off systemTranscriptional regulationTranscription factor

Identifiers

PMID42146592
PMCPMC13174685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.