Evidence map›Paper›PMID 42146591›Full record

ArticlebioRxiv : the preprint server for biology2026

A massively parallel reporter assay of

Rebecca Meyer-Schuman, Fisher Cherry, Yang Sui, Athanasios Papastathopoulos-Katsaros, Yi Zhong, Yidan Li, Tianyun Wang, Kelsey Hennick, Druha Karunakaran, Hanna Berk-Rauch and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rebecca Meyer-SchumanDepartment of Human and Molecular Genetics, Baylor College of Medicine, Houston TX 77030, USA.ORCID 0000-0002-2004-3505
Fisher CherryDepartment of Human and Molecular Genetics, Baylor College of Medicine, Houston TX 77030, USA.ORCID 0009-0001-7646-8422
Yang SuiDepartment of Genome Sciences, University of Washington School of Medicine, Seattle WA 98195, USA.ORCID 0000-0001-7285-8733
Athanasios Papastathopoulos-KatsarosJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston TX 77030, USA.ORCID 0000-0001-5695-176X
Yi ZhongJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston TX 77030, USA.
Yidan LiJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston TX 77030, USA.ORCID 0009-0007-3357-3808
Tianyun WangDepartment of Medical Genetics, Center for Medical Genetics, School of Basic Medical Sciences, Peking University, Beijing 100191, China.ORCID 0000-0002-5179-087X
Kelsey HennickDepartment of Neurological Surgery, University of California, San Francisco CA 94143, USA.ORCID 0000-0002-6127-2400
Druha KarunakaranCenter for Human Genetics and Genomics, New York University Grossman School of Medicine, New York NY 10016, USA.ORCID 0009-0002-8501-1624
Hanna Berk-RauchCenter for Human Genetics and Genomics, New York University Grossman School of Medicine, New York NY 10016, USA.ORCID 0000-0002-1238-1248
Zhandong LiuJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston TX 77030, USA.ORCID 0000-0002-7608-0831
Aravinda ChakravartiCenter for Human Genetics and Genomics, New York University Grossman School of Medicine, New York NY 10016, USA.ORCID 0000-0002-4264-2285
Tomasz NowakowskiDepartment of Neurological Surgery, University of California, San Francisco CA 94143, USA.ORCID 0000-0003-2345-4964
Evan E EichlerDepartment of Genome Sciences, University of Washington School of Medicine, Seattle WA 98195, USA.ORCID 0000-0002-8246-4014
Huda ZoghbiDepartment of Human and Molecular Genetics, Baylor College of Medicine, Houston TX 77030, USA.ORCID 0000-0002-0700-3349

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
Sporadic Mutations and Autism Spectrum DisordersR01MH101221 · NIMH · UNIVERSITY OF WASHINGTON · PI EICHLER, EVAN · 2013 to 2025
$9.2M
Defining critical MECP2 cis-regulatory elements towards identifying genetic candidates for male-biased autismF32HD116501 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI SCHUMAN, REBECCA MEYER · 2024 to 2025
$152k
NanoCellect WOLF Cell Sorter and N1 Single-Cell Dispenser SystemS10OD028591 · OD · BAYLOR COLLEGE OF MEDICINE · PI KIM, JEAN J · 2020 to 2020
$108k
NCI NIH HHS P30 CA125123NICHD NIH HHS F32 HD116501NICHD NIH HHS P50 HD103555NIH HHS S10 OD028591NIMH NIH HHS R01 MH101221
6 · The paper itself

Abstract

Autism affects males four times more often than females, yet the basis of this sex bias remains unclear. One hypothesis is that hypomorphic variants in X-linked genes-genes where loss-of-function alleles cause syndromic neurodevelopmental disorders (NDDs) predominantly in females-produce milder, non-syndromic phenotypes in hemizygous males. We tested this by investigating cis-regulatory elements (CREs) of

Identifiers

PMID42146591
PMCPMC13174625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.