Evidence map›Paper›PMID 42146587›Full record

ArticlebioRxiv : the preprint server for biology2026

Leiomodin 2 functions as a processive pointed-end elongator of actin filaments.

Sudipta Biswas, Tania M Larrinaga, Sandeep Choubey, Carol C Gregorio, Shashank Shekhar

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Sudipta BiswasDepartments of Physics, Biochemistry and Cell Biology, Emory University, Atlanta, GA 30322, USA.
Tania M LarrinagaDepartment of Cellular and Molecular Medicine and Sarver Molecular Cardiovascular Research Program, The University of Arizona, Tucson, AZ 85724, USA.
Sandeep ChoubeyThe Institute of Mathematical Sciences, Chennai 600113, India.
Carol C GregorioDepartment of Medicine and Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Shashank ShekharDepartments of Physics, Biochemistry and Cell Biology, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0003-1494-0151

Funding

Deciphering the role of Lmod2 in thin filament length regulation and dilated cardiomyopathyR01HL123078 · NHLBI · UNIVERSITY OF ARIZONA · PI Carol C Gregorio, Shashank Shekhar · 2015 to 2026
$5.6M
REGULATION OF THE ACTIN FILAMENT POINTED END DYNAMICS IN HEALTH AND DISEASER01GM120137 · NIGMS · WASHINGTON STATE UNIVERSITY · PI GALKIN, VITOLD, GREGORIO, CAROL C · 2017 to 2024
$4.0M
MULTICOMPONENT MECHANOCHEMICAL REGULATION OF ACTIN FILAMENT END DYNAMICSR35GM143050 · NIGMS · EMORY UNIVERSITY · PI Shashank Shekhar · 2021 to 2026
$2.7M
NHLBI NIH HHS R01 HL123078NIGMS NIH HHS R01 GM120137NIGMS NIH HHS R35 GM143050
6 · The paper itself

Abstract

The actin cytoskeleton drives essential processes like cell migration and muscle contraction. While barbed-end polymerization is well-established, pointed-end elongation was long considered impossible

Indexed as

Actin assemblyLeiomodinPointed-end elongationSarcomereThin filament

Identifiers

PMID42146587
PMCPMC13174315

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.