Evidence map›Paper›PMID 42146582›Full record

ArticlebioRxiv : the preprint server for biology2026

Intermolecular 3'UTR-3'UTR interactions drive Wnt gene activation through heteromeric protein assembly.

Ting Cai, Nelly M Cruz, Sudipto Basu, Richard M White, Christine Mayr

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ting CaiCancer Biology and Genetics Program, Sloan Kettering Institute, New York, NY 10065, USA.
Nelly M CruzCancer Biology and Genetics Program, Sloan Kettering Institute, New York, NY 10065, USA.
Sudipto BasuCancer Biology and Genetics Program, Sloan Kettering Institute, New York, NY 10065, USA.
Richard M WhiteNuffield Department of Medicine, Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK.
Christine MayrCancer Biology and Genetics Program, Sloan Kettering Institute, New York, NY 10065, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Regulation of protein multi-functionality by 3 UTRsR35GM144046 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Christine Mayr · 2022 to 2026
$3.5M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R35 GM144046
6 · The paper itself

Abstract

Stem cell differentiation depends on transcription factors that are often encoded by mRNAs with highly conserved 3'UTRs. To determine their functional roles, we performed 3'UTR loss-of-function studies. Partial deletion of endogenous 3'UTRs altered stem cell differentiation efficiency in 7/10 cases. As 6/7 3'UTR deletions did not affect expression level of the encoded proteins, we reveal widespread abundance-independent regulatory roles of 3'UTRs. For example, 3'UTR deletion of

Indexed as

3′UTR deletionantisense oligonucleotidesConserved 3′UTRco-translational heterodimerizationintermolecular mRNA-mRNA interactionsprotein abundance-independent regulationrepeatsRNA low complexity regionsstem cell differentiationWnt transcriptional programzebrafish embryogenesisβ-catenin

Identifiers

PMID42146582
PMCPMC13174568

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.