ArticlebioRxiv : the preprint server for biology2026
An underlying bistability sets amplitude and explains temperature compensation in the cyanobacterial circadian clock.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Circadian clocks create free-running biological rhythms with a period close to 24 hours. A universal property of these systems is temperature compensation, where the period of oscillation remains nearly invariant even as the amplitude changes with temperature. In the cyanobacterial system, where the core oscillator can be reconstituted from purified KaiABC proteins, we identify a key temperature-dependent positive feedback process: antagonism between KaiA and KaiB creates a bistable switch in protein-protein interaction. The region of bistability is strongly temperature dependent and correlated with oscillator amplitude. Combining this bistable mechanism with the temperature scaling of phosphorylation and dephosphorylation rates in a mathematical model recapitulates the overall temperature compensation of the oscillator. This capacity for history-dependent switching suggests that bistable dynamics underpin the generation of circadian rhythms.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.