Evidence map›Paper›PMID 42146547›Full record

ArticlebioRxiv : the preprint server for biology2026

Comprehensive Lineage Tracing Maps the Landscape of Cell Fate Decisions in Mouse Embryogenesis.

William N Colgan, Luke W Koblan, JoAnne Villagrana, Tien-Chi Jason Hou, Minming Wang, Gokul Gowri, Whitney Chandler, Leonardo A Sepúlveda, Didar Ciftci, Karina Smolyar and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

William N ColganWhitehead Institute for Biomedical Research; Cambridge MA, 02142, USA.ORCID 0000-0002-8328-4672
Luke W KoblanWhitehead Institute for Biomedical Research; Cambridge MA, 02142, USA.ORCID 0000-0003-2814-4412
JoAnne VillagranaDepartment of Genetics, Yale Stem Cell Center, Yale School of Medicine; New Haven CT 06519, USA.
Tien-Chi Jason HouDepartment of Genetics, Yale Stem Cell Center, Yale School of Medicine; New Haven CT 06519, USA.ORCID 0000-0002-8349-3132
Minming WangDepartment of Genetics, Yale Stem Cell Center, Yale School of Medicine; New Haven CT 06519, USA.ORCID 0000-0002-5377-5518
Gokul GowriWhitehead Institute for Biomedical Research; Cambridge MA, 02142, USA.
Whitney ChandlerWhitehead Institute for Biomedical Research; Cambridge MA, 02142, USA.
Leonardo A SepúlvedaHoward Hughes Medical Institute; Chevy Chase MD, 20815, USA.ORCID 0000-0003-3602-1009
Didar CiftciHoward Hughes Medical Institute; Chevy Chase MD, 20815, USA.
Karina SmolyarWhitehead Institute for Biomedical Research; Cambridge MA, 02142, USA.
Alicia YoungWhitehead Institute for Biomedical Research; Cambridge MA, 02142, USA.
Lars WittlerMax Planck Institute of Molecular Genetics, Max Planck Society, Berlin DE, 14195.
Styliani MarkoulakiWhitehead Institute for Biomedical Research; Cambridge MA, 02142, USA.
Kyle LohDepartment of Developmental Biology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford CA, 94305, USA.ORCID 0000-0002-8042-0149
Xiaowei ZhuangHoward Hughes Medical Institute; Chevy Chase MD, 20815, USA.
Nir YosefDepartment of Systems Immunology, Weizmann Institute of Science; Rehovot, 7610001, Israel.
Zachary D SmithDepartment of Genetics, Yale Stem Cell Center, Yale School of Medicine; New Haven CT 06519, USA.ORCID 0000-0002-9283-1957
Jonathan S WeissmanWhitehead Institute for Biomedical Research; Cambridge MA, 02142, USA.

Funding

Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human DiseaseRM1HG009490 · NHGRI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI Brittany S. Adamson, Martin Joseph Ankrah Aryee · 2017 to 2026
$22.7M
Epigenetic and environmental impact on early embryonic developmentDP2HD108774 · NICHD · YALE UNIVERSITY · PI SMITH, ZACHARY DYLAN · 2021 to 2024
$2.5M
Spatially-resolved, integrated cell state and lineage tracing to define progenitor cell dynamics in early mouse developmentK99HD118574 · NICHD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI Luke William Koblan · 2025 to 2026
$250k
NHGRI NIH HHS RM1 HG009490NICHD NIH HHS DP2 HD108774NICHD NIH HHS K99 HD118574
6 · The paper itself

Abstract

A comprehensive cell fate map of mammalian embryogenesis has remained out of reach due to the scale, cellular diversity, and non-deterministic nature of development

Identifiers

PMID42146547
PMCPMC13174701

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.