Evidence map›Paper›PMID 42146545›Full record

ArticlebioRxiv : the preprint server for biology2026

Osteocytes secrete adiponectin and display adipocyte-like phenotype under control of PPARG nuclear receptor.

Mohd Parvez Khan, Emily Crowe, Joshua Letson, Sudipta Baroi, Piotr J Czernik, Beata Lecka-Czernik

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohd Parvez KhanDepartment of Orthopaedic Surgery, College of Medicine and Life Sciences, University of Toledo, OH 43614.
Emily CroweDepartment of Orthopaedic Surgery, College of Medicine and Life Sciences, University of Toledo, OH 43614.
Joshua LetsonDepartment of Orthopaedic Surgery, College of Medicine and Life Sciences, University of Toledo, OH 43614.
Sudipta BaroiDepartment of Orthopaedic Surgery, College of Medicine and Life Sciences, University of Toledo, OH 43614.
Piotr J CzernikDepartment of Orthopaedic Surgery, College of Medicine and Life Sciences, University of Toledo, OH 43614.
Beata Lecka-CzernikDepartment of Orthopaedic Surgery, College of Medicine and Life Sciences, University of Toledo, OH 43614.ORCID 0000-0002-1216-9634

Funding

PPARG regulates osteocyte bioenergetics and function during agingR01AG071332 · NIA · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI GRIFFIN, PATRICK ROBERT, LECKA-CZERNIK, BEATA ANNA · 2021 to 2025
$3.4M
NIA NIH HHS R01 AG071332
6 · The paper itself

Abstract

Osteocytes and adipocytes represent cells with disparate functions. Osteocytes regulate bone metabolism (remodeling) and bone homeostasis, while adipocytes regulate energy metabolism and energy storage. Here, we demonstrate that osteocyte phenotype consists of adipocytic features which are under control of peroxisome proliferator-activated receptor gamma (PPARG), a master regulator of adipocyte differentiation and function. Using a mouse model with osteocyte-specific deletion of PPARG (OT

Indexed as

adipocyteadiponectinosteocyteperilipinsPPARgamma

Identifiers

PMID42146545
PMCPMC13174319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.