ArticlebioRxiv : the preprint server for biology2026
HIV-1 interactions with sialic acid-binding bacterial lectins promote virus infectivity in vitro and mucosal transmission in humanized mice.
Clauvis Kunkeng Yengo, Xiaomei Liu, Ries J Langley, Frida Avila, Manish Sagar, Christina Ochsenbauer, Barbara A Bensing, Catarina E Hioe
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Clauvis Kunkeng YengoDivision of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Xiaomei LiuDivision of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ries J LangleyMolecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.
Frida AvilaDepartment of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Manish SagarDepartment of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Christina OchsenbauerDepartment of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Barbara A BensingDepartment of Medicine, San Francisco Veterans Affairs Medical Center and University of California, San Francisco, CA, USA.
Catarina E HioeDivision of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-9245-9788 Funding
Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH, DEBBIE M. CHENG · 1998 to 2026
$51.7MUsing immune complex vaccines to optimize antibody responses to HIV EnvR01AI148327 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HIOE, CATARINA E · 2020 to 2025
$4.5MHarnessing Abs specific for immunogenic and conserved Env epitopes to protect against HIVR01AI139290 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HIOE, CATARINA E · 2018 to 2022
$4.1MAntibody dependent cellular cytotoxicity and HIV-1 mother to child transmissionR01AI172843 · NIAID · BOSTON MEDICAL CENTER · PI SAGAR, MANISH · 2022 to 2025
$3.5MBiologic consequences of HIV-1 interaction with bacteriaR21AI150909 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HIOE, CATARINA E · 2020 to 2021
$501kUsing streptococcal sialoglycan binding proteins to characterize MUC7 glycoformsR03DE029516 · NIDCR · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI BENSING, BARBARA ANNE · 2020 to 2021
$307kBLRD VA I01 BX005616BLRD VA IK6 BX004607NIAID NIH HHS P30 AI042853NIAID NIH HHS R01 AI139290NIAID NIH HHS R01 AI148327NIAID NIH HHS R01 AI172843NIAID NIH HHS R21 AI150909NIDCR NIH HHS R03 DE029516
6 · The paper itselfAbstract
Most HIV-1 transmission occurs at mucosal surfaces, which are colonized by the host microbiota. However, interactions between HIV and bacteria or bacterial products derived from the human microbiome are poorly characterized, and their biological consequences are largely unexplored. Here, we evaluated the effects of sialic acid-binding lectins expressed by bacterial species ubiquitous in the human microbiota on HIV-1 infectivity using viruses produced in 293T cells and human primary cells. We demonstrated that these bacterial lectins enhanced HIV-1 infectivity in a sialoglycan-dependent manner. Specifically, Siglec-like binding region lectins (SLBR-N, SLBR-H, and SLBR-B) from
Indexed as
HIV-1lectinsmucosal transmissionsialoglycantrans-infection
Identifiers
PMID42146538
PMCPMC13174408
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