Evidence map›Paper›PMID 42146515›Full record

ArticlebioRxiv : the preprint server for biology2026

Transposon end recognition and excision mechanisms of type I-F CRISPR-associated transposases.

Mateusz Walter, Giada Finocchio, Seraina Oberli, Iana C Hammerschmid, George D Lampe, Julia Karan, Thomas Swartjes, Samuel H Sternberg, Martin Jinek, Irma Querques

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Mateusz WalterMax Perutz Labs, Vienna BioCenter, 1030 Vienna, Austria.ORCID 0009-0001-7023-4545
Giada FinocchioDepartment of Biochemistry, University of Zurich, 8057 Zurich, Switzerland.ORCID 0000-0001-6905-9308
Seraina OberliDepartment of Biochemistry, University of Zurich, 8057 Zurich, Switzerland.ORCID 0000-0002-3568-7637
Iana C HammerschmidMax Perutz Labs, Vienna BioCenter, 1030 Vienna, Austria.ORCID 0009-0003-6670-6196
George D LampeDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, USA.ORCID 0000-0002-2873-2372
Julia KaranMax Perutz Labs, Vienna BioCenter, 1030 Vienna, Austria.ORCID 0009-0005-8284-7225
Thomas SwartjesMax Perutz Labs, Vienna BioCenter, 1030 Vienna, Austria.ORCID 0000-0001-7528-5483
Samuel H SternbergDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, USA.ORCID 0000-0001-8240-9114
Martin JinekDepartment of Biochemistry, University of Zurich, 8057 Zurich, Switzerland.ORCID 0000-0002-7601-210X
Irma QuerquesMax Perutz Labs, Vienna BioCenter, 1030 Vienna, Austria.ORCID 0000-0003-1113-2773

Funding

Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human DiseaseRM1HG009490 · NHGRI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI Brittany S. Adamson, Martin Joseph Ankrah Aryee · 2017 to 2026
$22.7M
ePACE: automation platforms for adaptable and scalable continuous evolution of biomolecules with therapeutic potentialR01EB027793 · NIBIB · BROAD INSTITUTE, INC. · PI Ahmad Samir Khalil, DAVID R LIU · 2019 to 2026
$6.1M
A high-performance and versatile technology for precision microbiome engineeringR01EB031935 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Samuel Henry Sternberg, Harris H Wang · 2021 to 2026
$3.3M
Leveraging Programmable Integrases for Human Genome EngineeringDP2HG011650 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STERNBERG, SAMUEL HENRY · 2020 to 2020
$2.4M
NHGRI NIH HHS DP2 HG011650NHGRI NIH HHS RM1 HG009490NIBIB NIH HHS R01 EB027793NIBIB NIH HHS R01 EB031935
6 · The paper itself

Abstract

CRISPR-associated transposons (CASTs) are Tn7-like elements that have co-opted RNA-guided CRISPR effectors for targeted DNA insertion. CASTs have been adapted as genome editing tools for programmable, site-specific integration. Among them, the type I-F system from

Identifiers

PMID42146515
PMCPMC13174479

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.