Evidence map›Paper›PMID 42146495›Full record

ArticlebioRxiv : the preprint server for biology2026

Identification of the cellular transcription factor KLF16 as a novel repressive epigenetic repressor of HIV-1 transcription.

Marion Santangelo, Maryam Bendoumou, Antoine Dutilleul, Soumia Khalfi, Estelle Plant, Christ Dominique Ngassaki-Yoka, Lisa Pilosio, Caroline Vanhulle, Jonathan Dias, Tristan Marray and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Marion SantangeloService of Molecular Virology, Department of Molecular Biology (DBM), Université libre de Bruxelles (ULB), Gosselies 6041, Belgium.
Maryam BendoumouService of Molecular Virology, Department of Molecular Biology (DBM), Université libre de Bruxelles (ULB), Gosselies 6041, Belgium.
Antoine DutilleulService of Molecular Virology, Department of Molecular Biology (DBM), Université libre de Bruxelles (ULB), Gosselies 6041, Belgium.
Soumia KhalfiDépartement de microbiologie, infectiologie et immunologie, Faculté de médecine, Université de Montréal, Montréal, Québec, Canada.
Estelle PlantService of Molecular Virology, Department of Molecular Biology (DBM), Université libre de Bruxelles (ULB), Gosselies 6041, Belgium.
Christ Dominique Ngassaki-YokaDépartement de microbiologie, infectiologie et immunologie, Faculté de médecine, Université de Montréal, Montréal, Québec, Canada.
Lisa PilosioService of Molecular Virology, Department of Molecular Biology (DBM), Université libre de Bruxelles (ULB), Gosselies 6041, Belgium.
Caroline VanhulleService of Molecular Virology, Department of Molecular Biology (DBM), Université libre de Bruxelles (ULB), Gosselies 6041, Belgium.
Jonathan DiasDépartement de microbiologie, infectiologie et immunologie, Faculté de médecine, Université de Montréal, Montréal, Québec, Canada.
Tristan MarrayService of Molecular Virology, Department of Molecular Biology (DBM), Université libre de Bruxelles (ULB), Gosselies 6041, Belgium.
Antoine FattaccioliResearch Unit in Cell Biology (URBC), Namur Research Institute for Life Sciences (Narilis), University of Namur (UNamur), Namur 5000, Belgium.
Marc DieuMass Spectrometry Platform (MaSUN), University of Namur (UNamur), Namur 5000, Belgium.
Jean-Pierre RoutyResearch Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Olivier RohrLaboratoire DHPI EA7292, Université de Strasbourg, Schiltigheim 67300, France.
Patricia RenardResearch Unit in Cell Biology (URBC), Namur Research Institute for Life Sciences (Narilis), University of Namur (UNamur), Namur 5000, Belgium.
Petronela AncutaDépartement de microbiologie, infectiologie et immunologie, Faculté de médecine, Université de Montréal, Montréal, Québec, Canada.ORCID 0000-0003-1922-5640
Carine VAN LintService of Molecular Virology, Department of Molecular Biology (DBM), Université libre de Bruxelles (ULB), Gosselies 6041, Belgium.

Funding

ERASE HIV: Enterprise for Research and Advancements to Stop and Eradicate HIVUM1AI164562 · NIAID · EMORY UNIVERSITY · PI Deanna A Kulpa, Mirko Paiardini · 2021 to 2026
$30.0M
NIAID NIH HHS UM1 AI164562
6 · The paper itself

Abstract

Despite antiretroviral therapy, human immunodeficiency virus type 1 (HIV-1) persists in latently-infected cells through epigenetic and transcriptional mechanisms. Latency-reversing agents have failed clinically, partly due to incomplete understanding of HIV-1 latency reversal. Here, using DNA-affinity capture and mass spectrometry on the HIV-1 5' long terminal repeat (5'LTR) enhancer-core promoter, we identify KLF16 (Krüppel-like Factor 16) as a novel regulator of HIV-1 gene expression. KLF16 binds to the HIV-1 5'LTR

Identifiers

PMID42146495
PMCPMC13174480

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.