Evidence map›Paper›PMID 42146491›Full record

ArticlebioRxiv : the preprint server for biology2026

An engineered disulfide staple restricts lid loop dynamics and alters substrate specificity of phenylalanine ammonia-lyase.

Rebecca Condruti, Likith Muthuraj, Jeevan K Prakash, Samuel D Littman, Pravin Kumar R, Nikhil U Nair

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rebecca CondrutiGraduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, United States.
Likith MuthurajDepartment of Protein Design and AI, Kcat Enzymatic Private Limited, Bengaluru 560005, Karnataka, India.
Jeevan K PrakashDepartment of Protein Design and AI, Kcat Enzymatic Private Limited, Bengaluru 560005, Karnataka, India.
Samuel D LittmanDepartment of Chemistry, Tufts University, Medford, MA 02155, United States.
Pravin Kumar RDepartment of Protein Design and AI, Kcat Enzymatic Private Limited, Bengaluru 560005, Karnataka, India.
Nikhil U NairGraduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, United States.ORCID 0000-0001-7737-1385

Funding

Strengthening gut barrier integrity with beneficial microbes to increase lifespan and healthspanR01AG069917 · NIA · TUFTS UNIVERSITY BOSTON · PI CROTT, JIMMY W · 2021 to 2025
$2.9M
Developing Synthetic Enzymes to Treat Inborn Errors of MetabolismR21HD105934 · NICHD · TUFTS UNIVERSITY MEDFORD · PI NAIR, NIKHIL UNNI · 2022 to 2023
$344k
NIA NIH HHS R01 AG069917NICHD NIH HHS R21 HD105934
6 · The paper itself

Abstract

In

Indexed as

Enzyme catalysisenzyme mutationinborn error of metabolismMDMLmolecular modelingphenylketonuriaPKUprotein engineeringQM/MM

Identifiers

PMID42146491
PMCPMC13174424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.