Evidence map›Paper›PMID 42146478›Full record

ArticlebioRxiv : the preprint server for biology2026

A MOPD II-associated Pericentrin variant disrupts PACT domain dimerization and pericentriolar material recruitment.

Makenzie S Thomas, Brian J Galletta, John M Ryniawec, Anastasia Amoiroglou, Chaitali Khan, Carey J Fagerstrom, Gregory C Rogers, Nasser M Rusan

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Makenzie S ThomasCell and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD.
Brian J GallettaCell and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD.
John M RyniawecDepartment of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona, Tucson, Arizona.
Anastasia AmoiroglouDepartment of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona, Tucson, Arizona.
Chaitali KhanCell and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD.
Carey J FagerstromCell and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD.
Gregory C RogersDepartment of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona, Tucson, Arizona.
Nasser M RusanCell and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD.

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Teri L Bankhead · 1985 to 2026
$110.2M
Regulation of Centrosome Asymmetry in Stem CellsZIAHL006126 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI RUSAN, NASSER · 2011 to 2025
$19.4M
Characterizing the molecular mechanisms of centriole duplication, growth and maturationR35GM136265 · NIGMS · UNIVERSITY OF ARIZONA · PI Gregory Charles Rogers · 2020 to 2026
$3.9M
Intramural NIH HHS ZIA HL006126NCI NIH HHS P30 CA023074NIGMS NIH HHS R35 GM136265
6 · The paper itself

Abstract

Centrosome dysfunction is linked to developmental disorders affecting brain and body size, including microcephaly and primordial dwarfism. However, the cellular mechanisms underlying these rare conditions remain poorly understood. In this study, we investigate a rare variant of the centrosome-associated protein Pericentrin, which was discovered in a single family with Majewski/microcephalic osteodysplastic primordial dwarfism type II (MOPD II). Unlike the majority of pathogenic

Indexed as

centriolecentrosomehuman disease modelingmicrocephalyMOPD IIPericentrin

Identifiers

PMID42146478
PMCPMC13174551

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.