Evidence map›Paper›PMID 42146472›Full record

ArticlebioRxiv : the preprint server for biology2026

COSMIC-Linked Ras Mutations at the Interface Between H-Ras and PI3Kγ

Elizabeth H Mead, Kaeden C Batz, Kuo-Hsien Shih, Ian R Fleming, Corey D Tesdahl, Lucas Lizardos, Joy R Armendariz, Jonathan P Hannan, Ava M Hickey, Alan Leyk and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Elizabeth H MeadDepartment of Biochemistry and Molecular Biophysics Program, University of Colorado at Boulder, Boulder, CO 80309-0596, USA.
Kaeden C BatzDepartment of Biochemistry and Molecular Biophysics Program, University of Colorado at Boulder, Boulder, CO 80309-0596, USA.
Kuo-Hsien ShihDepartment of Biochemistry and Molecular Biophysics Program, University of Colorado at Boulder, Boulder, CO 80309-0596, USA.
Ian R FlemingDepartment of Biochemistry and Molecular Biophysics Program, University of Colorado at Boulder, Boulder, CO 80309-0596, USA.
Corey D TesdahlDepartment of Biochemistry and Molecular Biophysics Program, University of Colorado at Boulder, Boulder, CO 80309-0596, USA.
Lucas LizardosDepartment of Biochemistry and Molecular Biophysics Program, University of Colorado at Boulder, Boulder, CO 80309-0596, USA.
Joy R ArmendarizDepartment of Biochemistry and Molecular Biophysics Program, University of Colorado at Boulder, Boulder, CO 80309-0596, USA.
Jonathan P HannanDepartment of Biochemistry and Molecular Biophysics Program, University of Colorado at Boulder, Boulder, CO 80309-0596, USA.
Ava M HickeyDepartment of Biochemistry and Molecular Biophysics Program, University of Colorado at Boulder, Boulder, CO 80309-0596, USA.
Alan LeykDepartment of Biochemistry and Molecular Biophysics Program, University of Colorado at Boulder, Boulder, CO 80309-0596, USA.
Annette H ErbseDepartment of Biochemistry and Molecular Biophysics Program, University of Colorado at Boulder, Boulder, CO 80309-0596, USA.
Joseph J FalkeDepartment of Biochemistry and Molecular Biophysics Program, University of Colorado at Boulder, Boulder, CO 80309-0596, USA.ORCID 0000-0002-3704-4694

Funding

Predoctoral Training Program in Signaling and Cellular Regulation INCLUDE Down Syndrome SupplementT32GM142607 · NIGMS · UNIVERSITY OF COLORADO · PI Sabrina Leigh Spencer, Tin Tin Su · 2021 to 2026
$3.6M
Mechanisms of Signaling on Membrane SurfacesR35GM144346 · NIGMS · UNIVERSITY OF COLORADO · PI JOSEPH J FALKE · 2022 to 2026
$2.0M
Modernization/operational improvements to basic centrifugation infrastructure of the Shared Instruments Pool in the Department of Biochemistry University of Colorado BoulderR24OD033699 · OD · UNIVERSITY OF COLORADO · PI ERBSE, ANNETTE H · 2022 to 2022
$143k
NIGMS NIH HHS R35 GM144346NIGMS NIH HHS T32 GM142607NIH HHS R24 OD033699
6 · The paper itself

Abstract

The three conventional isoforms of the Ras G-protein (H-, K-, N-Ras) function as molecular on-off switches that regulate a wide array of signaling pathways, including the Ras-PI3K-PIP

Identifiers

PMID42146472
PMCPMC13174291

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.