Evidence map›Paper›PMID 42146450›Full record

ArticlebioRxiv : the preprint server for biology2026

piRNA direct the chromatin reader to its genomic targets.

Yicheng Luo, Wenjiang Zhou, Zhaohui Jin, Baira Godneeva, Xiawei Huang, Haoqing Wang, Peng He, Ying Huang, Alexei A Aravin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yicheng LuoDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA.
Wenjiang ZhouDepartment of Pathology, University of California, San Francisco, San Francisco, CA, USA.
Zhaohui JinShanghai Key Laboratory of Biliary Tract Disease Research, Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Baira GodneevaDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA.
Xiawei HuangDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Haoqing WangStanford Cryo-Electron Microscopy Center, Stanford University, Palo Alto, CA, USA.
Peng HeDepartment of Pathology, University of California, San Francisco, San Francisco, CA, USA.
Ying HuangShanghai Key Laboratory of Biliary Tract Disease Research, Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Alexei A AravinDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA.ORCID 0000-0002-6956-8257

Funding

Molecular Mechanism of the piRNA BiogenesisR01GM097363 · NIGMS · CORNELL UNIVERSITY · PI ARAVIN, ALEXEI A. · 2011 to 2025
$4.0M
NIGMS NIH HHS R01 GM097363
6 · The paper itself

Abstract

The chromatin reader Rhino (Rhi) is an HP1-paralog and master regulator of piRNA biogenesis in

Identifiers

PMID42146450
PMCPMC13174600

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.