Evidence map›Paper›PMID 42146445›Full record

ArticlebioRxiv : the preprint server for biology2026

Spatial imprints of emergent cardiomyocyte states in the pressure-overloaded heart.

Yuening Liu, Annabelle M Coles, Jonah Castiglione, Vijay Venu Thiyagarajan, Kalen Clifton, Deevanshu Goyal, Jerry Wu, Arlo Sheridan, Ana Vujic, Kristen M Harris and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yuening LiuSalk Institute for Biological Studies, La Jolla, CA.ORCID 0000-0002-6891-0006
Annabelle M ColesSalk Institute for Biological Studies, La Jolla, CA.ORCID 0009-0001-0361-2067
Jonah CastiglioneSalk Institute for Biological Studies, La Jolla, CA.
Vijay Venu ThiyagarajanDepartment of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA.ORCID 0000-0002-8244-7150
Kalen CliftonDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD.ORCID 0000-0002-4095-8104
Deevanshu GoyalSalk Institute for Biological Studies, La Jolla, CA.ORCID 0000-0001-5239-9728
Jerry WuSalk Institute for Biological Studies, La Jolla, CA.ORCID 0009-0000-9441-106X
Arlo SheridanSalk Institute for Biological Studies, La Jolla, CA.ORCID 0000-0003-2907-2254
Ana VujicDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA.ORCID 0000-0002-0559-5299
Kristen M HarrisDepartment of Neuroscience, Center for Learning and Memory, University of Texas at Austin, Austin, TX.ORCID 0000-0002-1943-4744
Uri ManorDepartment of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA.ORCID 0000-0002-9802-1955
Talmo D PereiraSalk Institute for Biological Studies, La Jolla, CA.ORCID 0000-0001-9075-8365
Jean FanDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD.ORCID 0000-0002-0212-5451
Richard T LeeDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA.ORCID 0000-0003-4687-1381
Pallav KosuriSalk Institute for Biological Studies, La Jolla, CA.ORCID 0000-0002-7025-3543

Funding

Myocardial Physiology of Growth Differentiation Factor SignalingR01HL169291 · NHLBI · HARVARD UNIVERSITY · PI RICHARD T LEE · 2023 to 2026
$2.4M
Computational methods for delineating subcellular and cellular spatial transcriptional heterogeneity along developmental trajectoriesR35GM142889 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI FAN, JEAN · 2021 to 2025
$2.0M
Synaptic plasticity mechanisms that protect and refine local circuitsR56MH139176 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI HARRIS, KRISTEN M, ZITO, KAREN · 2024 to 2024
$467k
NHLBI NIH HHS R01 HL169291NIGMS NIH HHS R35 GM142889NIMH NIH HHS R56 MH139176
6 · The paper itself

Abstract

Resilience to cardiac stress is essential for health, yet the relationship between cardiomyocyte (CM) stress response and local microenvironment remains unclear. Here, we combined MERFISH spatial transcriptome profiling with

Identifiers

PMID42146445
PMCPMC13174657

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.