Evidence map›Paper›PMID 42146415›Full record

ArticlebioRxiv : the preprint server for biology2026

IL1β/IL1R1/IRAK4 Drives Inflammatory Ovarian Cancer Seeding at the inflamed sites and Is Reversed by an IRAK4 inhibitor UR241-2.

John P Miller, Kyu Kwang Kim, Cameron Wa Snyder, Negar Khazan, Niloy A Singh, Megan E Boyer, Elizabeth Lamere, Myla Strawderman, Sonali Sharma, Ronald Lakony and 15 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

John P MillerDepartment of Microbiology and Immunology, University of Rochester, Rochester, NY, USA,14642.
Kyu Kwang KimDepartment of Microbiology and Immunology, University of Rochester, Rochester, NY, USA,14642.
Cameron Wa SnyderDepartment of Microbiology and Immunology, University of Rochester, Rochester, NY, USA,14642.
Negar KhazanDepartment of Microbiology and Immunology, University of Rochester, Rochester, NY, USA,14642.
Niloy A SinghDepartment of Microbiology and Immunology, University of Rochester, Rochester, NY, USA,14642.
Megan E BoyerDepartment of Microbiology and Immunology, University of Rochester, Rochester, NY, USA,14642.
Elizabeth LamereDepartment of Medicine, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Myla StrawdermanDepartment of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, USA,14642.
Sonali SharmaDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA,14642.
Ronald LakonyDepartment of Medicine, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Michelle WhittumDepartment of Microbiology and Immunology, University of Rochester, Rochester, NY, USA,14642.
Mark AndersonEmpire Discovery Institute, University of Rochester, Rochester, NY, USA, 14642.
Rick KeenanEmpire Discovery Institute, University of Rochester, Rochester, NY, USA, 14642.
Elizabeth PritchettGenomic Research Center, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Cameron BakerGenomic Research Center, University of Rochester Medical Center, Rochester, NY, USA, 14642.
John AshtonGenomic Research Center, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Manoj K KheraPresude Lifesciences Private Limited, Delhi, India.
Michael R ElliottDepartment of Microbiology and Immunology, University of South Alabama, Mitchell Cancer Institute, Mobile, AL, USA, 36604.
Christina M AnnunziataAmerican Cancer Society, Atlanta, GA, USA, 30303.
Jeevisha BajajDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA,14642.ORCID 0000-0002-8411-6056
Laura M CalviDepartment of Medicine, University of Rochester Medical Center, Rochester, NY, USA, 14642.ORCID 0000-0001-6969-239X
Michael W BeckerPreviously at Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA; and Indiana University Simon Comprehensive Cancer Center, Indianapolis, Indiana, USA, 46202.
Rachael Rowswell-TurnerDepartment of Microbiology and Immunology, University of Rochester, Rochester, NY, USA,14642.
Richard G MooreDepartment of Microbiology and Immunology, University of Rochester, Rochester, NY, USA,14642.
Rakesh K SinghDepartment of Microbiology and Immunology, University of Rochester, Rochester, NY, USA,14642.ORCID 0000-0002-1124-9202

Funding

Targeting Microenvironmental Signals in Myeloid MalignanciesR01CA266617 · NCI · UNIVERSITY OF ROCHESTER · PI Jeevisha Bajaj · 2022 to 2026
$2.4M
Defining and Manipulating the Endothelial Niche in Myelodysplastic SyndromesR01DK133131 · NIDDK · UNIVERSITY OF ROCHESTER · PI BAJAJ, JEEVISHA · 2022 to 2024
$684k
NCI NIH HHS R01 CA266617NIDDK NIH HHS R01 DK133131
6 · The paper itself

Abstract

Inflammation-driven tumor implantation, such as port-site metastasis (PSM) following laparoscopic gynecologic surgery and peritoneal seeding during post-surgical recurrence, represents an aggressive clinical problem that remains poorly understood and lacks targeted therapies. To address this, we developed a non-surgical Mesothelium-Inflammation/Injury-Metastasis (MIM) model and investigated the role of the IL-1β/IL1R1/MYD88/IRAK1/4 axis and NLRP3 in epithelial ovarian cancer (EOC) seeding at inflamed or injured sites. This model created by a needle injury recapitulates inflammation-driven peritoneal seeding and mimics PSM and inflammation associated dissemination in peritoneum during recurrence. Seeding was dependent on Il1r1 but not Nlrp3, despite its role in regulating IL-1β production, as Il1ra

Identifiers

PMID42146415
PMCPMC13174620

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.