Evidence map›Paper›PMID 42146400›Full record

ArticlebioRxiv : the preprint server for biology2026

Rescuing the Function of Missense-Mutated Tumor Suppressor

Mariam Ahmed Fouad, Christopher S Parry, Sven A Miller, Shipra Malhotra, Glenn A Doyle, Ezra Shimabenga, Mashhura Nurilloeva, Elena Bondarenko, Grigorii V Andrianov, Wayne Childers and 6 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mariam Ahmed FouadCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.
Christopher S ParryCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.
Sven A MillerCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.
Shipra MalhotraCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.
Glenn A DoyleCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.
Ezra ShimabengaCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.
Mashhura NurilloevaCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.
Elena BondarenkoCancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia PA.
Grigorii V AndrianovCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.
Wayne ChildersMoulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, PA.
Benjamin E BlassMoulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, PA.
Petr B MakhovCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.
Johnathan R WhetstineCancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia PA.
Margie L ClapperCancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia PA.
Erica A GolemisCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.
John KaranicolasCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia PA.ORCID 0000-0003-0300-726X

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Margaret von Mehren · 1985 to 2026
$138.8M
TUFCCC/HC Regional Comprehensive Cancer Health PartnershipU54CA221705 · NCI · TEMPLE UNIV OF THE COMMONWEALTH · PI Joel Erblich, Jennifer S Ford · 2018 to 2026
$16.3M
Designing selective kinase inhibitors via deep learningR01GM141513 · NIGMS · RESEARCH INST OF FOX CHASE CAN CTR · PI RINK, LORI · 2022 to 2025
$2.4M
Deciphering Networks Controlling DNA AmplificationR35GM144131 · NIGMS · RESEARCH INST OF FOX CHASE CAN CTR · PI Johnathan R. Whetstine · 2022 to 2026
$2.3M
Identifying stabilizers of p53 using pocket complementarityR01GM112736 · NIGMS · RESEARCH INST OF FOX CHASE CAN CTR · PI KARANICOLAS, JOHN · 2016 to 2019
$1.6M
NCI NIH HHS P30 CA006927NCI NIH HHS U54 CA221705NIGMS NIH HHS R01 GM112736NIGMS NIH HHS R01 GM141513NIGMS NIH HHS R35 GM144131
6 · The paper itself

Abstract

Somatic mutations in the

Identifiers

PMID42146400
PMCPMC13174584

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.