Evidence map›Paper›PMID 42146398›Full record

ArticlebioRxiv : the preprint server for biology2026

Bis-hydroxylation of Homocitrulline Catalyzed by a Multinuclear Nonheme Iron-Dependent Oxidative Enzyme during RiPP Biosynthesis.

Dayna P Hebron, Tucker J Shriver, Joshua J Ziarek, Amy C Rosenzweig

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Dayna P HebronDepartments of Molecular Biosciences and of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0003-1950-0331
Tucker J ShriverDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States.ORCID 0009-0001-5121-8881
Joshua J ZiarekDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States.ORCID 0000-0002-3740-9999
Amy C RosenzweigDepartments of Molecular Biosciences and of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0001-8472-4134

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
TR&D 7: Cell Specific ProteomicsP41GM108569 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2015 to 2024
$13.6M
Metalloenzymes and metal homeostasisR35GM118035 · NIGMS · NORTHWESTERN UNIVERSITY · PI AMY C. ROSENZWEIG · 2016 to 2026
$7.1M
The role of dynamics in GPCR and arrestin allosteryR35GM143054 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI ZIAREK, JOSHUA JAMES · 2021 to 2025
$2.1M
Acquisition of a Thermo Fisher Scientific Q Exactive UHMR mass spectrometerS10OD025194 · OD · NORTHWESTERN UNIVERSITY · PI COMPTON, PHILIP DANIEL · 2018 to 2018
$795k
STRUCTURAL BIOL RES: LUNG SURFACTANT PROTEINS, DISTRESSS10RR019071 · NCRR · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 2005 to 2005
$272k
600 MHz NMR Instrument Upgrade at Northwestern UniversityS10OD012016 · OD · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 2012 to 2012
$267k
Entropic Redistribution Drives the GRK-Independent Binding of Arrestin 2 to the Cannabinoid 2 ReceptorF31DA060484 · NIDA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHRIVER, THOMAS · 2024 to 2025
$99k
NCI NIH HHS P30 CA060553NCRR NIH HHS S10 RR019071NIDA NIH HHS F31 DA060484NIGMS NIH HHS P41 GM108569NIGMS NIH HHS R35 GM118035NIGMS NIH HHS R35 GM143054NIH HHS S10 OD012016NIH HHS S10 OD025194
6 · The paper itself

Abstract

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are produced by biosynthetic enzymes that modify genetically encoded precursor peptide backbones and side chains. Genome mining and bioinformatics analyses targeting the multinuclear nonheme iron oxidative (MNIO) enzyme family led to the identification of a

Identifiers

PMID42146398
PMCPMC13174530

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.