Evidence map›Paper›PMID 42146391›Full record

ArticlebioRxiv : the preprint server for biology2026

Ryuma Tanaka, Banlanjo Umaru, Matthew Sobo, Shiva Senthil Kumar, Kathleen Dorris, Volker Hovestadt, Vijay Ramaswamy, Marc Remke, Ashley Margol, Charles B Stevenson and 13 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Ryuma TanakaDepartment of Pediatrics, Division of Hematology, Oncology, and Blood and Marrow Transplantation, Nationwide Children's Hospital, Columbus, Ohio, USA.
Banlanjo UmaruCenter for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, Ohio, USA.
Matthew SoboDepartment of Technical and Scientific Support, Diapharma, Cincinnati, Ohio, USA.
Shiva Senthil Kumar[Affiliation not provided].
Kathleen DorrisMorgan Adams Foundation Pediatric Brain Tumor Research Program, Children's Hospital Colorado, Aurora, Colorado, 80045, USA.
Volker HovestadtDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Vijay RamaswamyDivision of Hematology and Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.
Marc RemkeDepartment of Pediatric Hematology and Oncology, Saarland University Hospital, Homburg, Germany.
Ashley MargolDepartment of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Charles B StevensonDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Shahab AsgharzadehDivision of Hematology and Oncology, Children's Hospital of Los Angeles, Los Angeles, California, USA.
Stewart GoldmanPhoenix Children's Hospital, University of Arizona College of Medicine, Phoenix, Arizona, USA.
Lili MilesDepartment of Pathology and Laboratory Medicine, Nemours Children's Health System, Orlando, Florida, USA.
Jie HuangDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Katja von HoffDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Stefan RutkowskiDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Arzu Onar-ThomasDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Uri TaboriArthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada.
Michael TaylorTexas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, Texas, USA.
Stefan M PfisterHopp Children's Cancer Center Heidelberg (KiTZ); German Cancer Research Center (DKFZ); German Cancer Consortium (DKTK), Division of Pediatric Neuro-Oncology, Heidelberg, Germany.
Ralph SalloumDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Maryam FouladiDepartment of Pediatrics, Division of Hematology, Oncology, and Blood and Marrow Transplantation, Nationwide Children's Hospital, Columbus, Ohio, USA.
Rachid DrissiThe Ohio State University College of Medicine, Columbus, Ohio, USA.ORCID 0000-0003-0564-0181

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR026314 · NCRR · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E. · 2009 to 2011
$14.3M
Molecular Epidemiology in Children's Environmental Health Training Program (MECEH)T32ES010957 · NIEHS · UNIVERSITY OF CINCINNATI · PI Kelly J Brunst · 2001 to 2026
$11.1M
NCRR NIH HHS UL1 RR026314NIEHS NIH HHS T32 ES010957
6 · The paper itself

Abstract

Background: Telomerase reactivation, a hallmark of many cancers, is associated with expression of its catalytic subunit, hTERT. However, the prognostic significance of telomere maintenance mechanisms in pediatric medulloblastoma remains poorly defined. Methods: In this multi-institutional retrospective study of telomerase expression and Results: Among 74 patients with available Conclusion: Elevated

Indexed as

hTERTmedulloblastomamethylationMYC

Identifiers

PMID42146391
PMCPMC13174423

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.