Evidence map›Paper›PMID 42146390›Full record

ArticlebioRxiv : the preprint server for biology2026

MX2 Mediates Collapse of the HIV-1 Capsid.

Andrew Goodale, Szu-Wei Huang, Nathalia Almeida, Dave J Williamson, Nikoloz Shkriabai, Gilberto Betancor, Luis Apolonia, Frank DiMaio, Sergi Padilla-Parra, Mamuka Kvaratskhelia and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrew GoodaleRandall Centre for Cell and Molecular Biophysics, King's College London, London, UK.
Szu-Wei HuangDivision of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, Colorado, USA.
Nathalia AlmeidaDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK.
Dave J WilliamsonDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK.
Nikoloz ShkriabaiDivision of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, Colorado, USA.
Gilberto BetancorInstituto Universitario de Investigaciones Biomédicas y Sanitarias, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain.
Luis ApoloniaDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK.
Frank DiMaioInstitute for Protein Design, University of Washington, Seattle, USA.ORCID 0000-0002-7524-8938
Sergi Padilla-ParraDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK.
Mamuka KvaratskheliaDivision of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, Colorado, USA.
Julien R C BergeronRandall Centre for Cell and Molecular Biophysics, King's College London, London, UK.
Michael H MalimDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK.

Funding

Structural Biology CoreU54AI170855 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI Alan N. Engelman · 2022 to 2026
$36.7M
X-ray Crystallographic Fragment Screening CoreU54AI150472 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI OLSON, ARTHUR J. · 2019 to 2021
$15.7M
Ultra-potent HIV capsid inhibitorsR01AI157802 · NIAID · UNIVERSITY OF COLORADO DENVER · PI JAMES R FUCHS, Mamuka Kvaratskhelia · 2020 to 2026
$7.1M
NIAID NIH HHS R01 AI157802NIAID NIH HHS U54 AI150472NIAID NIH HHS U54 AI170855Wellcome Trust
6 · The paper itself

Abstract

The HIV-1 capsid core encapsulates the viral genome and mediates its delivery into the host cell's nucleus. It is composed of multiple copies of the Capsid (CA, p24

Identifiers

PMID42146390
PMCPMC13174526

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.