Evidence map›Paper›PMID 42146379›Full record

ArticlebioRxiv : the preprint server for biology2026

Mitochondrial dysfunction underlies cardiac contractility and growth defects in a zebrafish model of

Warlen P Piedade, Olivia Weeks, Hannah R Moran, Alexander A Akerberg, Michael M Molnar, Jennifer Galdieri, Ashley Buick, Rongbin Zheng, Kaifu Chen, Hasmik Keshishian and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Warlen P PiedadeDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, 02115.ORCID 0000-0002-6080-8701
Olivia WeeksDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, 02115.ORCID 0000-0003-1177-4848
Hannah R MoranHarvard Medical School, Boston, MA, 02115.
Alexander A AkerbergDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, 02115.ORCID 0000-0001-9385-3739
Michael M MolnarDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, 02115.
Jennifer GaldieriDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, 02115.ORCID 0009-0003-3008-4022
Ashley BuickDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, 02115.
Rongbin ZhengDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, 02115.ORCID 0000-0001-9928-2463
Kaifu ChenDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, 02115.ORCID 0000-0003-1009-4357
Hasmik KeshishianProteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA. 02140.ORCID 0000-0002-0062-9867
Patrick HartProteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA. 02140.
Steven A CarrProteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA. 02140.ORCID 0000-0002-7203-4299
Calum A MacRaeHarvard Medical School, Boston, MA, 02115.
Caroline E BurnsDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, 02115.ORCID 0000-0003-1565-7489
C Geoffrey BurnsDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, 02115.ORCID 0000-0002-5812-6621

Funding

RESEARCH METHODS IN PEDIATRICS HEART DISEASET32HL007572 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI Sarah D DE FERRANTI, Jane W. Newburger · 1985 to 2026
$13.0M
Change of InstitutionR35HL135831 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BURNS, CAROLINE E · 2017 to 2023
$4.2M
Targeting Endothelial Epsins to Ameliorate Myocardial IschemiaR01HL174928 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Hong Chen, Kaifu Chen · 2024 to 2026
$2.4M
Mechanistic dissection of 22q11.2DS in zebrafishR01HL171206 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CAROLINE E BURNS · 2024 to 2026
$1.9M
Bioinformatics Techniques to Analyze Dynamic Changes of 3D GenomeR01GM138407 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI CHEN, KAIFU · 2022 to 2025
$1.8M
Cardiovascular disease in fetal alcohol spectrum disorderU01AA030185 · NIAAA · BOSTON CHILDREN'S HOSPITAL · PI CAROLINE E BURNS, C. Geoffrey Burns · 2022 to 2026
$1.7M
Investigating the pro-regenerative potential of Pontin in the heart.R01HL176663 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI C. Geoffrey Burns · 2025 to 2026
$1.7M
Computational Technology for Single-Cell Functional GenomicsK99HG013662 · NHGRI · BOSTON CHILDREN'S HOSPITAL · PI Rongbin Zheng · 2025 to 2026
$261k
NHGRI NIH HHS K99 HG013662NHLBI NIH HHS R01 HL171206NHLBI NIH HHS R01 HL174928NHLBI NIH HHS R01 HL176663NHLBI NIH HHS R35 HL135831NHLBI NIH HHS T32 HL007572NIAAA NIH HHS U01 AA030185NIGMS NIH HHS R01 GM138407
6 · The paper itself

Abstract

Delineating the genetic and environmental instigators of congenital heart disease (CHD), affecting up to 1% of newborns, will improve preventative, diagnostic, and therapeutic efforts to mitigate disease outcomes. Although mutations in

Identifiers

PMID42146379
PMCPMC13174435

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.