Evidence map›Paper›PMID 42146377›Full record

ArticlebioRxiv : the preprint server for biology2026

TIR-like NADases act in bacterial immunity and the RNA vault.

Adam Osinski, Benjamin Mayro, Victor A Lopez, Jason Schrad, Hannah Choi, Diana R Tomchick, Krzysztof Pawłowski, Kevin Forsberg, Sarah H Shahmoradian, Vincent S Tagliabracci

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adam OsinskiDepartment of Molecular Biology, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.ORCID 0000-0003-0010-0733
Benjamin MayroDepartment of Molecular Biology, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Victor A LopezDepartment of Molecular Biology, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Jason SchradCenter for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, Dallas, TX, 75390, USA.ORCID 0000-0002-6695-7070
Hannah ChoiCenter for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, Dallas, TX, 75390, USA.ORCID 0009-0007-2167-445X
Diana R TomchickDepartment of Biochemistry, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.ORCID 0000-0002-7529-4643
Krzysztof PawłowskiDepartment of Molecular Biology, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Kevin ForsbergDepartment of Microbiology, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.ORCID 0000-0002-1545-8925
Sarah H ShahmoradianCenter for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, Dallas, TX, 75390, USA.ORCID 0000-0001-9752-7287
Vincent S TagliabracciDepartment of Molecular Biology, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.ORCID 0000-0002-9735-4678

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Clyde Smith · 2020 to 2026
$43.3M
Breathing life into dead enzymesDP2GM137419 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI TAGLIABRACCI, VINCENT SCOTT · 2019 to 2020
$2.6M
Discovery of bacterial defense and phage counter-defense strategiesDP2AI154402 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI FORSBERG, KEVIN J · 2021 to 2025
$2.6M
Discovering catalytic activities for pseudoenzymesR35GM158265 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Vincent Scott Tagliabracci · 2025 to 2026
$1.1M
Understanding the impact that tumor representative oxygen tension has on phosphotyrosine-dependent signaling networks in solid tumorsK00CA264162 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Benjamin Jacob Mayro · 2023 to 2026
$379k
NCI NIH HHS K00 CA264162NIAID NIH HHS DP2 AI154402NIGMS NIH HHS DP2 GM137419NIGMS NIH HHS P30 GM133894NIGMS NIH HHS R35 GM158265
6 · The paper itself

Abstract

Across all domains of life, organisms exploit NAD

Identifiers

PMID42146377
PMCPMC13174449

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.