Evidence map›Paper›PMID 42146354›Full record

ArticlebioRxiv : the preprint server for biology2026

HES3-dependent regulatory functions in development and fusion-positive rhabdomyosarcoma.

Jack Kucinski, Matthew R Kent, Katherine M Silvius, Ambuj Kumar, Cenny Taslim, Genevieve C Kendall

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jack KucinskiMolecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-1788-1305
Matthew R KentCenter for Childhood Cancer Research, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA.ORCID 0000-0002-8288-8714
Katherine M SilviusCenter for Childhood Cancer Research, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA.ORCID 0000-0003-3900-6381
Ambuj KumarCenter for Childhood Cancer Research, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA.
Cenny TaslimCenter for Childhood Cancer Research, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA.ORCID 0000-0003-3302-9099
Genevieve C KendallMolecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-3775-2006

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Understanding Infantile Rhabdomyosarcoma Biology and Therapeutic TargetsR01CA272872 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Genevieve Claire Kendall · 2022 to 2026
$2.1M
Training Program in Basic and Translational Pediatric Oncology ResearchT32CA269052 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI TIMOTHY P CRIPE · 2022 to 2026
$1.8M
NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA272872NCI NIH HHS T32 CA269052
6 · The paper itself

Abstract

HES3/Her3 is a transcription factor that functions in non-canonical STAT3 signaling to promote the renewal of neural stem cells and has roles in multiple cancer contexts. To study its role in development and disease, we previously generated a CRISPR/Cas9 zebrafish knockout of

Indexed as

cancer biologychromatin regulationdevelopmental biologyHES-family transcription factorsrhabdomyosarcoma

Identifiers

PMID42146354
PMCPMC13174599

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.