Evidence map›Paper›PMID 42146350›Full record

ArticlebioRxiv : the preprint server for biology2026

Integrated transcriptomic and proteomic analyses identify novel biomarkers of bladder outlet obstruction.

Alexander A Bigger-Allen, Barnali Das, Yang Tang, Kyle Costa, Gabriel Luis Ocampo, Ali Hashemi Gheinani, Shannon DiMartino, Jane Kaull, John W Froehlich, Richard Lee and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alexander A Bigger-AllenUrological Diseases Research Center, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0001-6914-9135
Barnali DasUrological Diseases Research Center, Boston Children's Hospital, Boston, MA, USA.
Yang TangUrological Diseases Research Center, Boston Children's Hospital, Boston, MA, USA.
Kyle CostaUrological Diseases Research Center, Boston Children's Hospital, Boston, MA, USA.
Gabriel Luis OcampoUrological Diseases Research Center, Boston Children's Hospital, Boston, MA, USA.
Ali Hashemi GheinaniFunctional Urology Research Group, Department for BioMedical Research DBMR, University of Bern, Switzerland.ORCID 0000-0002-9625-6259
Shannon DiMartinoUrological Diseases Research Center, Boston Children's Hospital, Boston, MA, USA.
Jane KaullUrological Diseases Research Center, Boston Children's Hospital, Boston, MA, USA.
John W FroehlichUrological Diseases Research Center, Boston Children's Hospital, Boston, MA, USA.
Richard LeeUrological Diseases Research Center, Boston Children's Hospital, Boston, MA, USA.
Rosalyn M AdamUrological Diseases Research Center, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-0943-6236

Funding

MECHANOTRANSDUCTION IN BLADDER SMOOTH MUSCLER01DK077195 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI ADAM, ROSALYN M · 2008 to 2018
$3.4M
NIMBLE: Non-Invasive Markers of Bladder DeteriorationR01DK127673 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI ADAM, ROSALYN M, LEE, RICHARD SANG-YONG · 2021 to 2025
$2.8M
NIDDK NIH HHS R01 DK077195NIDDK NIH HHS R01 DK127673
6 · The paper itself

Abstract

Bladder outlet obstruction leads to pathological remodeling and emergence of lower urinary tract symptoms. Although relief of obstruction is associated with symptomatic improvement, it is not universally successful, reflecting persistent alterations in the bladder. Reliable surrogate biomarkers of obstruction are lacking, particularly early in the disease course before irreversible damage to the bladder may have occurred. In this study, re-analysis of publicly available transcriptomic datasets from diverse rodent models of obstruction identified tissue transcripts including

Indexed as

inosineneurogenic bladderSpinal cord injuryurine biomarkers

Identifiers

PMID42146350
PMCPMC13174304

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.