Evidence map›Paper›PMID 42146336›Full record

ArticlebioRxiv : the preprint server for biology2026

CXCL13-CXCR5 Signaling in CD8

Daniel D Shapiro, Kye D Nichols, Moon Hee Lee, Pavlos Msaouel, Yuanshan Li, Yang Zong, Rong Hu, Wei Huang, Karla Esbona, Toshi Kinoshita and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Daniel D ShapiroDepartment of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Kye D NicholsDepartment of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Moon Hee LeeDepartment of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Pavlos MsaouelDepartment of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-6505-8308
Yuanshan LiDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Yang ZongDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Rong HuDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Wei HuangDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Karla EsbonaDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Toshi KinoshitaDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Paz LotanDepartment of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Daniel F RoadmanDepartment of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Everlyne NkadoriDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Stephanie M McGregorDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
David J BeebeDepartment of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.ORCID 0000-0002-0415-9006
Sheena C KerrCarbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.
Christian M CapitiniDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.ORCID 0000-0002-2276-6731
E Jason AbelDepartment of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Automated Tissue MicroarrayerS10OD023526 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI MATKOWSKYJ, KRISTINA A. · 2018 to 2018
$184k
NCI NIH HHS P30 CA014520NIH HHS S10 OD023526
6 · The paper itself

Abstract

Clear cell renal cell carcinoma (ccRCC) exhibits heterogeneity in immune infiltration and clinical outcomes, but the mechanisms governing recruitment and organization of tumor-reactive CD8

Indexed as

CD8 T cellchemokineCXCL13CXCR5immune microenvironmentkidney cancerrenal cell carcinomatumor microenvironment

Identifiers

PMID42146336
PMCPMC13174487

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.