ArticleACS omega2026
Function of miRNAs in Conferring Neuroprotection through a Tailored Peptide Derived from Snake Venom Nerve Growth Factor in Response to Paraquat-Induced Toxicity in
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Parkinson's disease (PD) is a major global health challenge, shaped by environmental factors and the accumulation of alpha-synuclein. MicroRNAs (miRNAs), key regulators of gene expression, play critical roles in neurodegeneration, and their dysregulation has been linked to PD development. Paraquat (PQ), a widely used herbicide, can induce PD-like symptoms by generating reactive oxygen species, impairing mitochondrial function, promoting alpha-synuclein aggregation, and triggering apoptosis of dopaminergic neurons. These effects ultimately alter the miRNA expression profiles. Our previous research demonstrated that the computationally designed snake venom-inspired peptide, heptadeca-neuropeptide (HNP), protects against PQ-induced toxicity and neurodegeneration in vitro (in rat PC-12 cells) and in vivo (in
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Registered trials
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