Evidence map›Paper›PMID 42146252›Full record

ArticleACS omega2026

Structural Basis for Potent Inhibition of Human DHODH by Quinoline-4-carboxylic Acid Derivatives.

Jéssika de Oliveira Viana, Tayná Rodrigues Olegário, Marília Cecília da Silva, Rodrigo Cristiano, Euzébio Guimarães Barbosa, Aline Dias da Purificação, Marina Sena Mendes, Diogo Boerin, Maria Cristina Nonato, Karen Cacilda Weber and 1 more

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jéssika de Oliveira VianaComputational Quantum Chemistry Laboratory, Department of Chemistry, Federal University of Paraíba, João Pessoa 58051-900, Paraíba, Brazil.ORCID https://orcid.org/0000-0001-6027-1759
Tayná Rodrigues OlegárioMedicinal Organic Synthesis Laboratory of Paraíba (LASOM-PB), Department of Chemistry, Federal University of Paraíba, João Pessoa 58051-900, Paraíba, Brazil.
Marília Cecília da SilvaComputational Quantum Chemistry Laboratory, Department of Chemistry, Federal University of Paraíba, João Pessoa 58051-900, Paraíba, Brazil.
Rodrigo CristianoMedicinal Organic Synthesis Laboratory of Paraíba (LASOM-PB), Department of Chemistry, Federal University of Paraíba, João Pessoa 58051-900, Paraíba, Brazil.ORCID https://orcid.org/0000-0002-5044-377X
Euzébio Guimarães BarbosaComputational Pharmaceutical Chemistry Laboratory, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Natal 59078-970, Rio Grande do Norte, Brazil.
Aline Dias da PurificaçãoCenter for the Research and Advancement of Fragments and Molecular Targets (CRAFT), School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-903, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-3127-7585
Marina Sena MendesCenter for the Research and Advancement of Fragments and Molecular Targets (CRAFT), School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-903, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-7144-9989
Diogo BoerinCenter for the Research and Advancement of Fragments and Molecular Targets (CRAFT), School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-903, São Paulo, Brazil.
Maria Cristina NonatoCenter for the Research and Advancement of Fragments and Molecular Targets (CRAFT), School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-903, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-4916-1505
Karen Cacilda WeberComputational Quantum Chemistry Laboratory, Department of Chemistry, Federal University of Paraíba, João Pessoa 58051-900, Paraíba, Brazil.ORCID https://orcid.org/0000-0003-4823-5290
Claudio Gabriel Lima-JuniorMedicinal Organic Synthesis Laboratory of Paraíba (LASOM-PB), Department of Chemistry, Federal University of Paraíba, João Pessoa 58051-900, Paraíba, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quinoline-4-carboxylic acid derivatives are privileged scaffolds in drug discovery, with potential as inhibitors of human dihydroorotate dehydrogenase (

Identifiers

PMID42146252
PMCPMC13176990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.