Extended Sustained Release of Propranolol Hydrochloride from Siloxane-Poly(propylene Oxide) Hybrid Material: A Multistep Mechanism.

Ranielle de Oliveira Silva, Karim Dahmouche, Celso V Santilli

Abstract read

In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ranielle de Oliveira SilvaSão Paulo State University (UNESP), Institute of Chemistry, Araraquara, São Paulo 14800-060, Brazil.ORCID https://orcid.org/0000-0001-9216-0543

Karim DahmoucheFederal University of Rio de Janeiro, Campus de Duque de Caxias, Duque de Caxias, Rio de Janeiro 25240-005, Brazil.

Celso V SantilliSão Paulo State University (UNESP), Institute of Chemistry, Araraquara, São Paulo 14800-060, Brazil.ORCID https://orcid.org/0000-0002-8356-8093

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An organic-inorganic hybrid composed of poly-(propylene oxide) (PPO) polymer chains cross-linked by siloxane nodes was selected as an amphiphilic hybrid carrier for the prolonged delivery of propranolol hydrochloride. Rubbery hybrid bodies were prepared according to a hydrolytic sol-gel route, without the use of catalysts. Efficient network formation was achieved by means of siloxane linkages, while preserving the integrity of the drug, as confirmed by

Identifiers

PMID42146213

DOI10.1021/acsomega.6c00982

PMCPMC13176998

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.