Evidence map›Paper›PMID 42146132›Full record

ArticleACS omega2026

Antiviral Activity of Dendritic Heparan Sulfate Mimetics against Respiratory Syncytial Virus and Herpes Simplex Virus‑1.

Yiming Yue, Amelia Chang, Sam Spijkers-Shaw, Rory Devlin, Ye Li, Phillip M Rendle, Ashley Nutsford, Blake Sullivan-Hill, Carol Wang, Olga V Zubkova and 2 more

Abstract read
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In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yiming YueSchool of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.
Amelia ChangDepartment of Molecular Medicine and Pathology, University of Auckland, Auckland 1010, New Zealand.
Sam Spijkers-ShawFerrier Research Institute, 69 Gracefield Road, Gracefield, Lower Hutt 5010, New Zealand.ORCID https://orcid.org/0009-0005-0606-3533
Rory DevlinFerrier Research Institute, 69 Gracefield Road, Gracefield, Lower Hutt 5010, New Zealand.
Ye LiFerrier Research Institute, 69 Gracefield Road, Gracefield, Lower Hutt 5010, New Zealand.
Phillip M RendleFerrier Research Institute, 69 Gracefield Road, Gracefield, Lower Hutt 5010, New Zealand.ORCID https://orcid.org/0000-0002-2825-8746
Ashley NutsfordDepartment of Molecular Medicine and Pathology, University of Auckland, Auckland 1010, New Zealand.
Blake Sullivan-HillDepartment of Molecular Medicine and Pathology, University of Auckland, Auckland 1010, New Zealand.
Carol WangSchool of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.
Olga V ZubkovaFerrier Research Institute, 69 Gracefield Road, Gracefield, Lower Hutt 5010, New Zealand.ORCID https://orcid.org/0000-0002-6892-8812
Natalie E NetzlerDepartment of Molecular Medicine and Pathology, University of Auckland, Auckland 1010, New Zealand.ORCID https://orcid.org/0000-0002-2259-3447
John A TaylorSchool of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.ORCID https://orcid.org/0000-0002-9060-4726

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heparan sulfate (HS) can act as an attachment receptor for many different animal viruses. Virus binding to HS occurs through electrostatic interactions between the negatively charged sulfate and carboxyl groups of HS and positively charged amino acids present in viral proteins. Soluble heparin, a glycosaminoglycan related to HS, can inhibit infection by many viruses, but the clinical use of heparin is limited by its anticoagulant activity. Synthetic HS mimetics that lack anticoagulant activity have been developed and can inhibit virus infection

Identifiers

PMID42146132
PMCPMC13177043

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.